On the Dependence of Rheology of Hyaluronic Acid Solutions and Frictional Behavior of Articular Cartilage

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dc.contributor.authorRebenda, Davidcs
dc.contributor.authorVrbka, Martincs
dc.contributor.authorČípek, Pavelcs
dc.contributor.authorToropitsyn, Evgeniycs
dc.contributor.authorNečas, Davidcs
dc.contributor.authorPravda, Martincs
dc.contributor.authorHartl, Martincs
dc.coverage.issue11cs
dc.coverage.volume13cs
dc.date.issued2020-06-11cs
dc.description.abstractHyaluronic acid (HA) injections represent one of the most common methods for the treatment of osteoarthritis. However, the clinical results of this method are unambiguous mainly because the mechanism of action has not been clearly clarified yet. Viscosupplementation consists, inter alia, of the improvement of synovial fluid rheological properties by injected solution. The present paper deals with the effect of HA molecular weight on the rheological properties of its solutions and also on friction in the articular cartilage model. Viscosity and viscoelastic properties of HA solutions were analyzed with a rotational rheometer in a cone–plate and plate–plate configuration. In total, four HA solutions with molecular weights between 77 kDa and 2010 kDa were tested. The frictional measurements were realized on a commercial tribometer Bruker UMT TriboLab, while the coefficient of friction (CoF) dependency on time was measured. The contact couple consisted of the articular cartilage pin and the plate made from optical glass. The contact was fully flooded with tested HA solutions. Results showed a strong dependency between HA molecular weight and its rheological properties. However, no clear dependence between HA molecular weight and CoF was revealed from the frictional measurements. This study presents new insight into the dependence between rheological and frictional behavior of the articular cartilage, while such an extensive investigation has not been presented before.ven
dc.formattextcs
dc.format.extent1-14cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMaterials . 2020, vol. 13, issue 11, p. 1-14.en
dc.identifier.doi10.3390/ma13112659cs
dc.identifier.issn1996-1944cs
dc.identifier.orcid0000-0002-5407-1336cs
dc.identifier.orcid0000-0002-2845-3752cs
dc.identifier.orcid0000-0002-6556-1816cs
dc.identifier.orcid0000-0002-3843-8732cs
dc.identifier.orcid0000-0001-5432-6645cs
dc.identifier.other164235cs
dc.identifier.researcheridB-1770-2017cs
dc.identifier.researcheridF-5568-2012cs
dc.identifier.researcheridB-1777-2017cs
dc.identifier.researcheridI-7816-2014cs
dc.identifier.researcheridD-8261-2012cs
dc.identifier.scopus56635672600cs
dc.identifier.scopus7005196946cs
dc.identifier.urihttp://hdl.handle.net/11012/189282
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofMaterialscs
dc.relation.urihttps://www.mdpi.com/1996-1944/13/11/2659/htmcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1996-1944/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectarticular cartilageen
dc.subjecthyaluronic aciden
dc.subjectrheologyen
dc.subjectfrictionen
dc.titleOn the Dependence of Rheology of Hyaluronic Acid Solutions and Frictional Behavior of Articular Cartilageen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164235en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:48:36en
sync.item.modts2025.01.17 15:36:43en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav konstruovánícs
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