Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility

Simple item page
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorStrmiska, Vladislavcs
dc.contributor.authorDostálová, Simonacs
dc.contributor.authorMichálek, Petrcs
dc.contributor.authorKřížková, Soňacs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorHynek, Davidcs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.date.issued2017-12-31cs
dc.description.abstractThe current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The resulting RuNPs were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The cytotoxic effects of the complex were tested using cell lines representing breast and ovarian cancers and neuroblastoma. Although bare RuNPs had only negligible cytotoxicity, RuPDox caused an enhancement of doxorubicin cytotoxicity when compared to free doxorubicin. RuPDox promoted significantly increased stability of doxorubicin in human plasma and pronounced hemocompatibility assayed on human red blood cells. Results demonstrate that biocompatible RuNPs could have a great potential as versatile nanoplatform to enhance efficiency of anticancer therapy.en
dc.formattextcs
dc.format.extent837-842cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMendelNet 2017. 2017, p. 837-842.en
dc.identifier.isbn978-80-7509-529-9cs
dc.identifier.orcid0000-0002-7036-1640cs
dc.identifier.orcid0000-0002-0121-0128cs
dc.identifier.orcid0000-0002-0479-8369cs
dc.identifier.orcid0000-0003-4216-9544cs
dc.identifier.orcid0000-0002-7318-6470cs
dc.identifier.orcid0000-0002-8288-3999cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.other148707cs
dc.identifier.researcheridH-2870-2018cs
dc.identifier.researcheridB-9180-2014cs
dc.identifier.researcheridE-9617-2012cs
dc.identifier.researcheridE-5711-2012cs
dc.identifier.researcheridE-5702-2012cs
dc.identifier.researcheridN-9991-2014cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.scopus6603604023cs
dc.identifier.scopus12040049600cs
dc.identifier.urihttp://hdl.handle.net/11012/84172
dc.language.isoencs
dc.publisherMendel University in Brnocs
dc.relation.ispartofMendelNet 2017cs
dc.relation.urihttps://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4cs
dc.rights(C) Mendel University in Brnocs
dc.rights.accessopenAccesscs
dc.subjectBiocompatibilityen
dc.subjectnanomedicineen
dc.subjectpolyvinylpyrrolidoneen
dc.subjectpolyoxyethylene stearateen
dc.titleRuthenium-based core-shell nanoparticles with exceptional in vitro biocompatibilityen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-148707en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:26en
sync.item.modts2025.01.17 18:33:46en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
MendelNet_mnt2017010092.pdf
Size:
313.22 KB
Format:
Adobe Portable Document Format
Description:
MendelNet_mnt2017010092.pdf
Download
Collections
Chytré nanonástroje