Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

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dc.contributor.authorGandalovičová, Anetacs
dc.contributor.authorRösel, Danielcs
dc.contributor.authorFernandes, Michaelcs
dc.contributor.authorVeselý, Pavelcs
dc.contributor.authorHenenberg, Petrcs
dc.contributor.authorČermák, Vladimírcs
dc.contributor.authorPetruželka, Lubošcs
dc.contributor.authorKumar, Sunilcs
dc.contributor.authorSanz-Moreno, Victoriacs
dc.contributor.authorBrábek, Jancs
dc.coverage.issue6cs
dc.coverage.volume3cs
dc.date.issued2017-06-01cs
dc.description.abstractIn solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ‘migrastatics’ for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers.en
dc.formattextcs
dc.format.extent391-406cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationTrends in Cancer. 2017, vol. 3, issue 6, p. 391-406.en
dc.identifier.doi10.1016/j.trecan.2017.04.008cs
dc.identifier.issn2405-8033cs
dc.identifier.orcid0000-0003-3420-395Xcs
dc.identifier.other136334cs
dc.identifier.researcheridD-9921-2012cs
dc.identifier.urihttp://hdl.handle.net/11012/84149
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofTrends in Cancercs
dc.relation.urihttps://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2405-8033/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectsolid canceren
dc.subjectmetastasisen
dc.subjectinvasionen
dc.subjecttreatmenten
dc.subjectcontractilityen
dc.subjectmigrastaticsen
dc.titleMigrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challengesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-136334en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:42en
sync.item.modts2025.01.17 18:35:34en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Experimentální biofotonikacs
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