Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges
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Date
2017-06-01
Authors
Gandalovičová, Aneta
Rösel, Daniel
Fernandes, Michael
Veselý, Pavel
Henenberg, Petr
Čermák, Vladimír
Petruželka, Luboš
Kumar, Sunil
Sanz-Moreno, Victoria
Brábek, Jan
ORCID
0000-0003-3420-395XAdvisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
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Abstract
In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ‘migrastatics’ for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers.
Description
Citation
Trends in Cancer. 2017, vol. 3, issue 6, p. 391-406.
https://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7
https://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7
Document type
Peer-reviewed
Document version
Published version
Date of access to the full text
Language of document
en