Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

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dc.contributor.authorPermyakova, Elizavetacs
dc.contributor.authorAntipina, Liubov Yu.cs
dc.contributor.authorKiryukhantsev-Korneev, Philipcs
dc.contributor.authorKovalskii, Andreycs
dc.contributor.authorPolčák, Josefcs
dc.contributor.authorManakhov, Antoncs
dc.contributor.authorGudz, Kristina Yu.cs
dc.contributor.authorSorokin, Pavel B.cs
dc.contributor.authorShtansky, Dmitry V.cs
dc.coverage.issue12cs
dc.coverage.volume9cs
dc.date.issued2019-12-01cs
dc.description.abstractA new low-pressure plasma-based approach to activate the surface of BN nanoparticles (BNNPs) in order to facilitate the attachment of folate acid (FA) molecules for cancer-specific therapy is described. Plasma treatment of BNNPs (BNNPs(PT)) was performed in a radiofrequency plasma reactor using ethylene and carbon dioxide monomers. The carboxyl groups deposited on the surface of BNNPs(PT) were activated by N,N'-dicyclohexylcarbodiimide (DCC) and participated in the condensation reaction with ethylene diamine (EDA) to form a thin amino-containing layer (EDA-BNNPPT). Then, the DCC-activated FA was covalently bonded with BNNPs(PT) by a chemical reaction between amino groups of EDA-BNNPs(PT) and carboxyl groups of FA. Density functional theory calculations showed that the pre-activation of FA by DCC is required for grafting of the FA to the EDA-BNNPs(PT). It was also demonstrated that after FA immobilization, the electronic characteristics of the pteridine ring remain unchanged, indicating that the targeting properties of the FA/EDA-BNNPs(PT) nanohybrids are preserved.en
dc.description.abstractA new low-pressure plasma-based approach to activate the surface of BN nanoparticles (BNNPs) in order to facilitate the attachment of folate acid (FA) molecules for cancer-specific therapy is described. Plasma treatment of BNNPs (BNNPs(PT)) was performed in a radiofrequency plasma reactor using ethylene and carbon dioxide monomers. The carboxyl groups deposited on the surface of BNNPs(PT) were activated by N,N'-dicyclohexylcarbodiimide (DCC) and participated in the condensation reaction with ethylene diamine (EDA) to form a thin amino-containing layer (EDA-BNNPPT). Then, the DCC-activated FA was covalently bonded with BNNPs(PT) by a chemical reaction between amino groups of EDA-BNNPs(PT) and carboxyl groups of FA. Density functional theory calculations showed that the pre-activation of FA by DCC is required for grafting of the FA to the EDA-BNNPs(PT). It was also demonstrated that after FA immobilization, the electronic characteristics of the pteridine ring remain unchanged, indicating that the targeting properties of the FA/EDA-BNNPs(PT) nanohybrids are preserved.en
dc.formattextcs
dc.format.extent1-14cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNanomaterials. 2019, vol. 9, issue 12, p. 1-14.en
dc.identifier.doi10.3390/nano9121658cs
dc.identifier.issn2079-4991cs
dc.identifier.orcid0000-0002-6571-6291cs
dc.identifier.other162084cs
dc.identifier.researcheridD-8130-2012cs
dc.identifier.scopus25632811000cs
dc.identifier.urihttp://hdl.handle.net/11012/184682
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofNanomaterialscs
dc.relation.urihttps://www.mdpi.com/2079-4991/9/12/1658cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2079-4991/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBN nanoparticlesen
dc.subjectchemical vapor depositionen
dc.subjectplasma surface polymerizationen
dc.subjectfolic acid conjugatesen
dc.subjectdrug delivery nanocarriersen
dc.subjectdensity functional theoryen
dc.subjectBN nanoparticles
dc.subjectchemical vapor deposition
dc.subjectplasma surface polymerization
dc.subjectfolic acid conjugates
dc.subjectdrug delivery nanocarriers
dc.subjectdensity functional theory
dc.titlePlasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Studyen
dc.title.alternativePlasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Studyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-162084en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 15:19:28en
sync.item.modts2025.10.14 09:57:52en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Sdílená laboratoř RP1cs
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