Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

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dc.contributor.authorPermyakova, Elizavetacs
dc.contributor.authorAntipina, Liubov Yu.cs
dc.contributor.authorKiryukhantsev-Korneev, Philipcs
dc.contributor.authorKovalskii, Andreycs
dc.contributor.authorPolčák, Josefcs
dc.contributor.authorManakhov, Antoncs
dc.contributor.authorGudz, Kristina Yu.cs
dc.contributor.authorSorokin, Pavel B.cs
dc.contributor.authorShtansky, Dmitry V.cs
dc.coverage.issue12cs
dc.coverage.volume9cs
dc.date.accessioned2020-08-04T11:04:41Z
dc.date.available2020-08-04T11:04:41Z
dc.date.issued2019-12-01cs
dc.description.abstractA new low-pressure plasma-based approach to activate the surface of BN nanoparticles (BNNPs) in order to facilitate the attachment of folate acid (FA) molecules for cancer-specific therapy is described. Plasma treatment of BNNPs (BNNPs(PT)) was performed in a radiofrequency plasma reactor using ethylene and carbon dioxide monomers. The carboxyl groups deposited on the surface of BNNPs(PT) were activated by N,N'-dicyclohexylcarbodiimide (DCC) and participated in the condensation reaction with ethylene diamine (EDA) to form a thin amino-containing layer (EDA-BNNPPT). Then, the DCC-activated FA was covalently bonded with BNNPs(PT) by a chemical reaction between amino groups of EDA-BNNPs(PT) and carboxyl groups of FA. Density functional theory calculations showed that the pre-activation of FA by DCC is required for grafting of the FA to the EDA-BNNPs(PT). It was also demonstrated that after FA immobilization, the electronic characteristics of the pteridine ring remain unchanged, indicating that the targeting properties of the FA/EDA-BNNPs(PT) nanohybrids are preserved.en
dc.formattextcs
dc.format.extent1-14cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNanomaterials. 2019, vol. 9, issue 12, p. 1-14.en
dc.identifier.doi10.3390/nano9121658cs
dc.identifier.issn2079-4991cs
dc.identifier.other162084cs
dc.identifier.urihttp://hdl.handle.net/11012/184682
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofNanomaterialscs
dc.relation.urihttps://www.mdpi.com/2079-4991/9/12/1658cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2079-4991/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBN nanoparticlesen
dc.subjectchemical vapor depositionen
dc.subjectplasma surface polymerizationen
dc.subjectfolic acid conjugatesen
dc.subjectdrug delivery nanocarriersen
dc.subjectdensity functional theoryen
dc.titlePlasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Studyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-162084en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:04:41en
sync.item.modts2020.08.04 12:21:56en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Sdílená laboratoř RP1cs
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