but.defence	Student Milan Pospíšil úspěšně obhájil svou diplomovou práci a prokázal znalosti v oblasti teorie v rámci odborné rozpravy.	cs
but.jazyk	angličtina (English)
but.program	Bioengineering	cs
but.result	práce byla úspěšně obhájena	cs
dc.contributor.advisor	Paštěka, Richard	en
dc.contributor.author	Pospíšil, Milan	en
dc.contributor.referee	Forjan, Mathias	en
dc.date.accessioned	2023-01-20T07:53:19Z
dc.date.available	2023-01-20T07:53:19Z
dc.date.created	2022	cs
dc.description.abstract	The objectives are to analyze the mechanisms of airflow and particle transport in the extrathoracic airways. Understanding these features in greater detail not only helps in the treatment of diseases related to the respiratory tract but also aims to reduce the amount of animal testing. For the evaluation, computational fluid dynamic (CFD) simulations were utilized. ANSYS was used as a leading software to perform a simulation of different inspiratory flow rates. In this work, Large Eddy Simulations (LES) is engaged due to its real-world performance. The geometry of the upper airways is obtained from CT scans, to preserve the topological data of the upper airways. Furthermore, the deposition of inhaled particles of varying diameters 1-10 m was examined, helping us better understand the therapeutic effects of inhaled particles. Two types of inhalations simulations were carried out. First, inhalation through the nose, simulating the inhalation with a nebulizer with airflow rates of 15 l/min and 30 l/min. Second, through mouth simulating inhalation with a dry-powder inhaler with a flow rate of 90 l/min. Simulated results show that most of the particles deposit at the entrance of the nasal or oral cavity. When flow rates of 15 and 30 l/min were compared, it can be seen the higher initial velocity is, the particles of large diameter (6-10 m) are stuck in the nasal cavity and do not appear in the laryngeal region, whereas with low velocity the more particles of 6-10 m can be found in this region. The maximum number of particles leaving the trachea was observed with a flow rate of 15 l/min, accounting for 26 %. As opposed to 90 l/min where only 13 % left the upper respiratory tract. Also, typical pressure drop can be observed in pressure contours describing the larynx region. This was most significant for a flow rate of 90 l/min where the pressure from the oropharynx to subglottis dropped by 490 Pa.	en
dc.description.abstract	The objectives are to analyze the mechanisms of airflow and particle transport in the extrathoracic airways. Understanding these features in greater detail not only helps in the treatment of diseases related to the respiratory tract but also aims to reduce the amount of animal testing. For the evaluation, computational fluid dynamic (CFD) simulations were utilized. ANSYS was used as a leading software to perform a simulation of different inspiratory flow rates. In this work, Large Eddy Simulations (LES) is engaged due to its real-world performance. The geometry of the upper airways is obtained from CT scans, to preserve the topological data of the upper airways. Furthermore, the deposition of inhaled particles of varying diameters 1-10 m was examined, helping us better understand the therapeutic effects of inhaled particles. Two types of inhalations simulations were carried out. First, inhalation through the nose, simulating the inhalation with a nebulizer with airflow rates of 15 l/min and 30 l/min. Second, through mouth simulating inhalation with a dry-powder inhaler with a flow rate of 90 l/min. Simulated results show that most of the particles deposit at the entrance of the nasal or oral cavity. When flow rates of 15 and 30 l/min were compared, it can be seen the higher initial velocity is, the particles of large diameter (6-10 m) are stuck in the nasal cavity and do not appear in the laryngeal region, whereas with low velocity the more particles of 6-10 m can be found in this region. The maximum number of particles leaving the trachea was observed with a flow rate of 15 l/min, accounting for 26 %. As opposed to 90 l/min where only 13 % left the upper respiratory tract. Also, typical pressure drop can be observed in pressure contours describing the larynx region. This was most significant for a flow rate of 90 l/min where the pressure from the oropharynx to subglottis dropped by 490 Pa.	cs
dc.description.mark	A	cs
dc.identifier.citation	POSPÍŠIL, M. Modelování charakteristik proudění vzduchu a ukládání částic v horním dýchacím traktu člověka pomocí CFD simulací [online]. Brno: Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. 2022.	cs
dc.identifier.other	137477	cs
dc.identifier.uri	http://hdl.handle.net/11012/208763
dc.language.iso	en	cs
dc.publisher	Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií	cs
dc.rights	Standardní licenční smlouva - přístup k plnému textu bez omezení	cs
dc.subject	Upper Respiratory Tract (URT)	en
dc.subject	Particle Deposition	en
dc.subject	Aerosol Inhalation	en
dc.subject	Computational Fluid Dynamics (CFD) Simulation	en
dc.subject	Upper Respiratory Tract (URT)	cs
dc.subject	Particle Deposition	cs
dc.subject	Aerosol Inhalation	cs
dc.subject	Computational Fluid Dynamics (CFD) Simulation	cs
dc.title	Modelování charakteristik proudění vzduchu a ukládání částic v horním dýchacím traktu člověka pomocí CFD simulací	en
dc.title.alternative	Modeling of Airflow Characteristics and Particle Deposition in Human Upper Respiratory Tract Using CFD Simulations	cs
dc.type	Text	cs
dc.type.driver	masterThesis	en
dc.type.evskp	diplomová práce	cs
dcterms.dateAccepted	2022-11-09	cs
dcterms.modified	2023-01-19-14:24:50	cs
eprints.affiliatedInstitution.faculty	Fakulta elektrotechniky a komunikačních technologií	cs
sync.item.dbid	137477	en
sync.item.dbtype	ZP	en
sync.item.insts	2023.01.20 08:53:19	en
sync.item.modts	2023.01.20 08:12:41	en
thesis.discipline	bez specializace	cs
thesis.grantor	Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrství	cs
thesis.level	Inženýrský	cs
thesis.name	Ing.	cs

Modelování charakteristik proudění vzduchu a ukládání částic v horním dýchacím traktu člověka pomocí CFD simulací

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