Short-term effects of transcranial direct current stimulation on motor speech in Parkinson's disease: a pilot study

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dc.contributor.authorBrabenec, Lubošcs
dc.contributor.authorKováč, Danielcs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorŘehulková, Lenkacs
dc.contributor.authorKábrtová, Veronikacs
dc.contributor.authorRektorová, Irenacs
dc.coverage.issue1cs
dc.coverage.volume131cs
dc.date.accessioned2024-12-10T13:55:31Z
dc.date.available2024-12-10T13:55:31Z
dc.date.issued2024-04-09cs
dc.description.abstractIntroduction: Hypokinetic dysarthria (HD) is a common motor speech symptom of Parkinson's disease (PD) which does not respond well to PD treatments. We investigated short-term effects of transcranial direct current stimulation (tDCS) on HD in PD using acoustic analysis of speech. Based on our previous studies we focused on stimulation of the right superior temporal gyrus (STG) - an auditory feedback area. Methods: In 14 PD patients with HD, we applied anodal, cathodal and sham tDCS to the right STG using a cross-over design. A protocol consisting of speech tasks was performed prior to and immediately after each stimulation session. Linear mixed models were used for the evaluation of the effects of each stimulation condition on the relative change of acoustic parameters. We also performed a simulation of the mean electric field induced by tDCS. Results: Linear mixed model showed a statistically significant effect of the stimulation condition on the relative change of median duration of silences longer than 50 ms (p = 0.015). The relative change after the anodal stimulation (mean = -5.9) was significantly lower as compared to the relative change after the sham stimulation (mean = 12.8), p = 0.014. We also found a correlation between the mean electric field magnitude in the right STG and improvement of articulation precision after anodal tDCS (R = 0.637; p = 0.019). Conclusions: The exploratory study showed that anodal tDCS applied over the auditory feedback area may lead to shorter pauses in a speech of PD patients.en
dc.formattextcs
dc.format.extent791-797cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJOURNAL OF NEURAL TRANSMISSION. 2024, vol. 131, issue 1, p. 791-797.en
dc.identifier.doi10.1007/s00702-024-02771-5cs
dc.identifier.issn1435-1463cs
dc.identifier.orcid0000-0003-2701-1802cs
dc.identifier.orcid0000-0002-6195-193Xcs
dc.identifier.other188497cs
dc.identifier.researcheridK-4001-2015cs
dc.identifier.scopus57268698100cs
dc.identifier.scopus35746344400cs
dc.identifier.urihttps://hdl.handle.net/11012/249747
dc.language.isoencs
dc.publisherSPRINGER WIENcs
dc.relation.ispartofJOURNAL OF NEURAL TRANSMISSIONcs
dc.relation.urihttps://link.springer.com/article/10.1007/s00702-024-02771-5cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1435-1463/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectParkinson's diseaseen
dc.subjectHypokinetic dysarthriaen
dc.subjectTranscranial electric stimulationen
dc.subjectAcoustic analysisen
dc.subjectSuperior temporal gyrusen
dc.titleShort-term effects of transcranial direct current stimulation on motor speech in Parkinson's disease: a pilot studyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188497en
sync.item.dbtypeVAVen
sync.item.insts2024.12.10 14:55:31en
sync.item.modts2024.12.02 15:32:09en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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