G-Quadruplexes as Sensing Probes

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dc.contributor.authorRuttkay-Nedecký, Branislavcs
dc.contributor.authorKudr, Jiřícs
dc.contributor.authorNejdl, Lukášcs
dc.contributor.authorMašková, Darinacs
dc.contributor.authorKizek, Renécs
dc.contributor.authorAdam, Vojtěchcs
dc.coverage.issue12cs
dc.coverage.volume18cs
dc.date.issued2013-12-01cs
dc.description.abstractGuanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.en
dc.formattextcs
dc.format.extent14760-14779cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMOLECULES. 2013, vol. 18, issue 12, p. 14760-14779.en
dc.identifier.doi10.3390/molecules181214760cs
dc.identifier.issn1420-3049cs
dc.identifier.orcid0000-0001-6332-8917cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.other145126cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.urihttp://hdl.handle.net/11012/137244
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofMOLECULEScs
dc.relation.urihttps://www.mdpi.com/1420-3049/18/12/14760cs
dc.rightsCreative Commons Attribution 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1420-3049/cs
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/cs
dc.subjectG-quadruplexen
dc.subjectDNAzymeen
dc.subjectheminen
dc.titleG-Quadruplexes as Sensing Probesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-145126en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:49:46en
sync.item.modts2025.01.17 18:32:27en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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