Electrospun Ethyl-<i>p</i>-Methoxycinnamate Loaded CS/PEG/PLA Nanofibers

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dc.contributor.authorDinh, Do Thics
dc.contributor.authorPhuong, Ngo Thics
dc.contributor.authorThuy, Nguyen Thi Thucs
dc.contributor.authorNhung, Pham Thics
dc.contributor.authorHung, Le Ngoccs
dc.contributor.authorHuyen, Do Thi Thanhcs
dc.contributor.authorAn, Nguyen Thaics
dc.contributor.authorŽídek, Jancs
dc.contributor.authorLe Minh, Hacs
dc.coverage.issue1cs
dc.coverage.volume12cs
dc.date.accessioned2025-07-31T11:56:04Z
dc.date.available2025-07-31T11:56:04Z
dc.date.issued2025-01-01cs
dc.description.abstractIn this study, the characteristic properties and biological activities of the electrospun nanofibers made of polymers including chitosan (CS), polyethylene glycol (PEG), and polylactic acid (PLA) loaded with 15% of a natural anti-inflammatory and analgesic agent, ethyl p-methoxycinnamate (EPMC), were reported. The morphological and chemical characteristics of the fibers were analyzed using a scanning electron microscope and Fourier transform infrared spectra, respectively. The mechanical properties and hydrophilicity of the nanofibers were also investigated. Research on the release of the bioactive compound EPMC from the nanofibers in phosphate-buffered saline medium showed that about 70% of EPMC was released after 24 h. The significant anti-inflammatory effect of the nanofibers was evaluated via inhibition of nitric oxide production in RAW264.7 cells stimulated by lipopolysaccharide with an IC50 value of 41.05 +/- 1.75 mu g/mL. Besides, the nanofibers also exhibited anti-bacterial activity and were proved to be safe both in vitro and in vivo. The results suggested that the nanofibers CS/PEG/PLA loaded with ethyl p-methoxycinnamate may be a potential candidate for developing biomedical products related to inflammation.en
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationAATCC Journal of Research. 2025, vol. 12, issue 1, p. 1-11.en
dc.identifier.doi10.1177/24723444241288284cs
dc.identifier.issn2330-5517cs
dc.identifier.other198203cs
dc.identifier.urihttps://hdl.handle.net/11012/255371
dc.language.isoencs
dc.publisherSAGE PUBLICATIONS INCcs
dc.relation.ispartofAATCC Journal of Researchcs
dc.relation.urihttps://journals.sagepub.com/doi/10.1177/24723444241288284cs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2330-5517/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectAnti-Inflammatory Effecten
dc.subjectChitosanen
dc.subjectElectrospinningen
dc.subjectEthyl <italic>p</italic>-Methoxycinnamateen
dc.subjectNanofibersen
dc.subjectPolyethylene Glycolen
dc.subjectPolylactic Aciden
dc.titleElectrospun Ethyl-<i>p</i>-Methoxycinnamate Loaded CS/PEG/PLA Nanofibersen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-198203en
sync.item.dbtypeVAVen
sync.item.insts2025.07.31 13:56:04en
sync.item.modts2025.07.31 13:32:55en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé polymerní materiály a kompozitcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé biomateriálycs
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