Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents

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dc.contributor.authorPilat, Floriancs
dc.contributor.authorSchwarz, Benediktcs
dc.contributor.authorBaumgartner, Bettinacs
dc.contributor.authorRistanic, Danielacs
dc.contributor.authorDetz, Hermanncs
dc.contributor.authorAndrews, Aaron Maxwellcs
dc.contributor.authorLendl, Bernhardcs
dc.contributor.authorStrasser, Gottfriedcs
dc.contributor.authorHinkov, Borislavcs
dc.coverage.issue7cs
dc.coverage.volume23cs
dc.date.issued2023-03-28cs
dc.description.abstractQuality control of liquids is an important part of analytical chemistry. The gold standard for measuring residual water in organic solvents and pharmaceutical applications is Karl Fischer titration. It has a high sensitivity, selectivity and accuracy. The downsides are a time-consuming offline analysis, together with the need for toxic reagents producing waste, and it suffers from poor inter-laboratory reproducibility. In this work, we present a high-performance lab-on-a-chip sensor exploiting mid-IR spectroscopy for liquid sensing. It is operating at 6.1 mu m wavelength and is suitable for robust and flexible real-time in situ analysis of the residual water concentration in isopropyl alcohol. This is demonstrated in two experiments. A custom-made 60 mu L flow cell is employed to measure only minute amounts of analyte in an inline configuration. In a second approach, the whole sensor is immersed into the analyte to demonstrate sensitive and rapid in situ operation on the millisecond time scale. This is confirmed by the ability for time resolved single water-droplet monitoring, while they are mixed into the liquid sample. We obtain a limit of detection between 120 ppm and 150 ppm with a concentration coverage spanning three orders of magnitude from 1.2 x 10(-2)%(vol) to 25%(vol) for the flow cell and 1.5 x 10(-2)%(vol) to 19%(vol) in the in situ configuration, respectively.en
dc.formattextcs
dc.format.extent1816-1824cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationLAB ON A CHIP. 2023, vol. 23, issue 7, p. 1816-1824.en
dc.identifier.doi10.1039/d2lc00724jcs
dc.identifier.issn1473-0189cs
dc.identifier.orcid0000-0002-4167-3653cs
dc.identifier.other183758cs
dc.identifier.urihttp://hdl.handle.net/11012/213677
dc.language.isoencs
dc.publisherRoyal Society of Chemistrycs
dc.relation.ispartofLAB ON A CHIPcs
dc.relation.urihttps://pubs.rsc.org/en/content/articlelanding/2023/LC/D2LC00724Jcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1473-0189/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectFT-IRen
dc.subjectORGANIC-SOLVENTSen
dc.subjectWAVE-GUIDESen
dc.subjectIN-VITROen
dc.subjectSPECTROSCOPYen
dc.subjectTEMPERATUREen
dc.subjectLASERen
dc.titleBeyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solventsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183758en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:40en
sync.item.modts2025.01.17 18:46:27en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Epitaxní materiály a nanostrukturycs
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Epitaxní materiály a nanostruktury