Thermoresistant Newcastle disease vaccine effectivelyprotects SPF, native, and commercial chickens inchallenge with virulent virus

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dc.contributor.authorAbdoshah, Mohammadcs
dc.contributor.authorHassanzadeh, Mohammadcs
dc.contributor.authorMasoudi, Shahincs
dc.contributor.authorAshtari, Abbascs
dc.contributor.authorYousefi, Alirezacs
dc.contributor.authorPartovi Nasr, Minoocs
dc.coverage.issue4cs
dc.coverage.volume8cs
dc.date.issued2023-03-07cs
dc.description.abstractBackground: Due to the more stability and a better homogenecity in immune response, the use of thermoresistant vaccines in different chicken types has been increased. Objective: This study aimed to evaluate the efficacy of a newly developed Newcastle disease vaccine (ND.TR.IR ) originating from 1-2 strain in specific pathogen-free (SPF) and native and broiler chickens. Methods: Following determination of pathogenicity indices on the candidate seed, three efficacy examinations were conducted. In the first experiment, 120 1-day-old SPF chickens were randomly allocated to six groups and either vaccinated with ND.TR.IR via eye drop at 1, 7, and 21 days of age (V-1, V-7, and V-21), or considered as non-vaccinated control groups (C-1, C-7, and C-21). At 20th post-vaccination day, sera hemag-glutination inhibition (HI) antibody titres against ND virus (NDV) were measured and then the chickens were challenged by virulent NDV (vNDV). In the second and third experiments, the efficacy of ND.TR.IR vaccine was compared to routine vaccination program (B1 and LaSota) in native and broiler chickens that were vaccinated at 10 and 20 days of age, respectively. The HI antibody titres were measured on 10, 20, 30, and 40 days of age, and also challenge efficacy test with vNDV was conducted on 30 days of age. Results: The studied virus, as a vaccinal seed, complied with the pathogenicity indices of avirulent NDV and molecular identity of 1-2 strain. In the efficacy evaluation trials, the vaccinated chickens had higher HI antibody titres against NDV compared with their corresponding control chickens (p < 0.05). Results of the challenge tests indicated 95% and 100% protection against vNDV in native, SPF, and broiler-vaccinated chickens, respectively. Conclusions: The present findings indicated that administration of ND.TR.IR induced appropriate HI antibody titres against NDV in SPF, native, and broiler chickens associated with good protection in efficacy test.en
dc.formattextcs
dc.format.extent1539-1546cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationVeterinary Medicine and Science. 2023, vol. 8, issue 4, p. 1539-1546.en
dc.identifier.doi10.1002/vms3.794cs
dc.identifier.issn2053-1095cs
dc.identifier.other183045cs
dc.identifier.urihttp://hdl.handle.net/11012/213622
dc.language.isoencs
dc.publisherWiley-VCHcs
dc.relation.ispartofVeterinary Medicine and Sciencecs
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/vms3.794cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2053-1095/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectchickenen
dc.subjectefficacyen
dc.subjectNewcastle diseaseen
dc.subjectthermoresistanten
dc.subjectvaccineen
dc.titleThermoresistant Newcastle disease vaccine effectivelyprotects SPF, native, and commercial chickens inchallenge with virulent virusen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183045en
sync.item.dbtypeVAVen
sync.item.insts2024.03.06 14:45:29en
sync.item.modts2024.03.06 14:13:37en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Fakulta elektrotechniky a komunikačních technologiícs
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