Genomic and Phenotypic Comparison of Polyhydroxyalkanoates Producing Strains of genus Caldimonas/Schlegelella

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dc.contributor.authorMusilová, Janacs
dc.contributor.authorKouřilová, Xeniecs
dc.contributor.authorHeřmánková, Kristýnacs
dc.contributor.authorBezdíček, Matějcs
dc.contributor.authorIeremenko, Anastasiiacs
dc.contributor.authorDvořák, Pavelcs
dc.contributor.authorObruča, Stanislavcs
dc.contributor.authorSedlář, Karelcs
dc.coverage.issueNovembercs
dc.coverage.volume21cs
dc.date.issued2023-10-30cs
dc.description.abstractPolyhydroxyalkanoates (PHAs) have emerged as an environmentally friendly alternative to conventional polyesters. In this study, we present a comprehensive analysis of the genomic and phenotypic characteristics of three non-model thermophilic bacteria known for their ability to produce PHAs: Schlegelella aquatica LMG 23380T, Caldimonas thermodepolymerans DSM 15264, and C. thermodepolymerans LMG 21645 and the results were compared with the type strain C. thermodepolymerans DSM 15344T. We have assembled the first complete genomes of these three bacteria and performed the structural and functional annotation. This analysis has provided valuable insights into the biosynthesis of PHAs and has allowed us to propose a comprehensive scheme of carbohydrate metabolism in the studied bacteria. Through phylogenomic analysis, we have confirmed the synonymity between Caldimonas and Schlegelella genera, and further demonstrated that S. aquatica and S. koreensis, currently classified as orphan species, belong to the Caldimonas genus.en
dc.description.abstractPolyhydroxyalkanoates (PHAs) have emerged as an environmentally friendly alternative to conventional polyesters. In this study, we present a comprehensive analysis of the genomic and phenotypic characteristics of three non-model thermophilic bacteria known for their ability to produce PHAs: Schlegelella aquatica LMG 23380T, Caldimonas thermodepolymerans DSM 15264, and C. thermodepolymerans LMG 21645 and the results were compared with the type strain C. thermodepolymerans DSM 15344T. We have assembled the first complete genomes of these three bacteria and performed the structural and functional annotation. This analysis has provided valuable insights into the biosynthesis of PHAs and has allowed us to propose a comprehensive scheme of carbohydrate metabolism in the studied bacteria. Through phylogenomic analysis, we have confirmed the synonymity between Caldimonas and Schlegelella genera, and further demonstrated that S. aquatica and S. koreensis, currently classified as orphan species, belong to the Caldimonas genus.en
dc.formattextcs
dc.format.extent5372-5381cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationComputational and Structural Biotechnology Journal. 2023, vol. 21, issue November, p. 5372-5381.en
dc.identifier.doi10.1016/j.csbj.2023.10.051cs
dc.identifier.issn2001-0370cs
dc.identifier.orcid0000-0001-6910-6047cs
dc.identifier.orcid0000-0002-1339-6660cs
dc.identifier.orcid0009-0002-6720-0499cs
dc.identifier.orcid0000-0002-9270-195Xcs
dc.identifier.orcid0000-0002-8269-4020cs
dc.identifier.other185013cs
dc.identifier.researcheridAHB-1545-2022cs
dc.identifier.researcheridK-1120-2014cs
dc.identifier.scopus25621797900cs
dc.identifier.scopus56309904900cs
dc.identifier.urihttp://hdl.handle.net/11012/244318
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofComputational and Structural Biotechnology Journalcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2001037023004075cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2001-0370/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectCaldimonasen
dc.subjectSchlegelellaen
dc.subjectde novo assemblyen
dc.subjectPHAsen
dc.subjectNext-Generation Industrial Biotechnologyen
dc.subjectLMG 23380Ten
dc.subjectDSM 15264en
dc.subjectLMG 21645en
dc.subjectDSM 15344Ten
dc.subjectCaldimonas
dc.subjectSchlegelella
dc.subjectde novo assembly
dc.subjectPHAs
dc.subjectNext-Generation Industrial Biotechnology
dc.subjectLMG 23380T
dc.subjectDSM 15264
dc.subjectLMG 21645
dc.subjectDSM 15344T
dc.titleGenomic and Phenotypic Comparison of Polyhydroxyalkanoates Producing Strains of genus Caldimonas/Schlegelellaen
dc.title.alternativeGenomic and Phenotypic Comparison of Polyhydroxyalkanoates Producing Strains of genus Caldimonas/Schlegelellaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-185013en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 14:07:44en
sync.item.modts2025.10.14 09:34:50en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs

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