Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

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dc.contributor.authorUrbánková, Lenkacs
dc.contributor.authorHorký, Pavelcs
dc.contributor.authorSkládanka, Jiřícs
dc.contributor.authorPřibilová, Magdalenacs
dc.contributor.authorSmolíková, Vendulacs
dc.contributor.authorNevrkla, Pavelcs
dc.contributor.authorCernei, Natalia Vladimirovnacs
dc.contributor.authorLacková, Zuzanacs
dc.contributor.authorHedbávný, Josefcs
dc.contributor.authorRidošková, Andreacs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorKopel, Pavelcs
dc.coverage.issuee4862cs
dc.coverage.volume6cs
dc.date.accessioned2020-08-04T11:04:14Z
dc.date.available2020-08-04T11:04:14Z
dc.date.issued2018-05-28cs
dc.description.abstractBackground: Selenium is an essential element; however, at higher doses, it can be toxic. Therefore, alternative nanotechnological solutions are required to overcome toxicological issues, rather than conventional alternatives. Nanoparticles show new and promising properties that may be able to suppress toxicity while maintaining the positive effects of selenium on an organism. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles (SeNPs) on the antioxidant status of rats. Methods: The males of the outbreed rat strain Wistar albino were selected as a model organism. Animals were fed different forms of selenium. The control group was given a mixture without selenium addition, whereas other groups were fed a mixture containing sodium selenite, Se-49, and Se-100 SeNPs respectively. The duration of the trial was 30 days. Results: Analysis of blood and liver was performed where the concentration of reduced (GSH) and oxidised (GSSG) glutathione, and total selenium content were measured. In the liver, a significant reduction in GSSG was found for all experiment groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion: These results show that SeNPs may be an alternative to dietary selenium for animal organisms.en
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPeerJ. 2018, vol. 6, issue e4862, p. 1-11.en
dc.identifier.doi10.7717/peerj.4862cs
dc.identifier.issn2167-8359cs
dc.identifier.other148533cs
dc.identifier.urihttp://hdl.handle.net/11012/83821
dc.language.isoencs
dc.publisherPeerJcs
dc.relation.ispartofPeerJcs
dc.relation.urihttps://peerj.com/articles/4862.pdfcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2167-8359/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectSelenium nanoparticlesen
dc.subjectGlutathioneen
dc.subjectRaten
dc.subjectAnimal nutritionen
dc.subjectAntioxidanten
dc.titleAntioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticlesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-148533en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:04:14en
sync.item.modts2020.08.04 12:28:38en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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