Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA

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dc.contributor.authorJyoti, Jyotics
dc.contributor.authorMuoz Martin, Jose Mariacs
dc.contributor.authorPumera, Martincs
dc.coverage.issue50cs
dc.coverage.volume15cs
dc.date.accessioned2024-02-22T13:46:24Z
dc.date.available2024-02-22T13:46:24Z
dc.date.issued2023-12-11cs
dc.description.abstractQuantum dot-based materials have been found to be excellent platforms for biosensing and bioimaging applications. Herein, self-propelled microrobots made of graphene quantum dots (GQD-MRs) have been synthesized and explored as unconventional dynamic biocarriers toward the optical "on-the-fly" monitoring of DNA. As a first demonstration of applicability, GQD-MRs have been first biofunctionalized with a DNA biomarker (i.e., fluorescein amidite-labeled, FAM-L) via hydrophobic pi-stacking interactions and subsequently exposed toward different concentrations of a DNA target. The biomarker-target hybridization process leads to a biomarker release from the GQD-MR surface, resulting in a linear alteration in the fluorescence intensity of the dynamic biocarrier at the nM range (1-100 nM, R-2 = 0.99), also demonstrating excellent selectivity and sensitivity, with a detection limit as low as 0.05 nM. Consequently, the developed dynamic biocarriers, which combine the appealing features of GQDs (e.g., water solubility, fluorescent activity, and supramolecular pi-stacking interactions) with the autonomous mobility of MRs, present themselves as potential autonomous micromachines to be exploited as highly efficient and sensitive "on-the-fly" biosensing systems. This method is general and can be simply customized by tailoring the biomarker anchored to the GQD-MR's surface.en
dc.formattextcs
dc.format.extent58548-58555cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS applied materials & interfaces. 2023, vol. 15, issue 50, p. 58548-58555.en
dc.identifier.doi10.1021/acsami.3c09920cs
dc.identifier.issn1944-8252cs
dc.identifier.orcid0000-0001-9529-6980cs
dc.identifier.orcid0000-0001-5846-2951cs
dc.identifier.other186982cs
dc.identifier.researcheridF-2724-2010cs
dc.identifier.scopus56377080700cs
dc.identifier.urihttps://hdl.handle.net/11012/245192
dc.language.isoencs
dc.publisherAMER CHEMICAL SOCcs
dc.relation.ispartofACS applied materials & interfacescs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsami.3c09920cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1944-8252/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmicrorocketsen
dc.subjectfluorescenceen
dc.subjectself-propelledmicromotorsen
dc.subjectDNA biosensoren
dc.subjectFRETen
dc.titleQuantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNAen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-186982en
sync.item.dbtypeVAVen
sync.item.insts2024.02.22 14:46:24en
sync.item.modts2024.02.22 14:12:55en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
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