Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

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dc.contributor.authorJanasik, Dawidcs
dc.contributor.authorJasinski, Krzysztofcs
dc.contributor.authorWeglarz, Wladyslav P.cs
dc.contributor.authorNemec, Ivancs
dc.contributor.authorJewula, Pawelcs
dc.contributor.authorKrawczyk, Tomaszcs
dc.coverage.issue8cs
dc.coverage.volume94cs
dc.date.issued2022-03-14cs
dc.description.abstractHydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.en
dc.formattextcs
dc.format.extent3427-3431cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationAnalytical Chemistry. 2022, vol. 94, issue 8, p. 3427-3431.en
dc.identifier.doi10.1021/acs.analchem.1c04978cs
dc.identifier.issn1520-6882cs
dc.identifier.orcid0000-0003-3231-7849cs
dc.identifier.orcid0000-0002-2586-7685cs
dc.identifier.other177356cs
dc.identifier.researcheridA-6969-2010cs
dc.identifier.researcheridJ-5254-2018cs
dc.identifier.scopus57201282084cs
dc.identifier.scopus24554099800cs
dc.identifier.urihttp://hdl.handle.net/11012/204475
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofAnalytical Chemistrycs
dc.relation.urihttps://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04978cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1520-6882/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectMagnetic resonance imagingen
dc.subjectFluorineen
dc.subjectpHen
dc.subjectMolecular structureen
dc.subjectNuclear magnetic resonance spectroscopyen
dc.titleRatiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switchesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-177356en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:50en
sync.item.modts2025.01.17 15:19:15en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Magneto-Optická a THz Spektroskopiecs
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