Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
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Date
2022-03-14
Authors
Janasik, Dawid
Jasinski, Krzysztof
Weglarz, Wladyslav P.
Nemec, Ivan
Jewula, Pawel
Krawczyk, Tomasz
0000-0003-3231-7849Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
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Abstract
Hydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.
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Citation
Analytical Chemistry. 2022, vol. 94, issue 8, p. 3427-3431.
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04978
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04978
Document type
Peer-reviewed
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Published version
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Language of document
en