Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation

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dc.contributor.authorNovotná, Lenkacs
dc.contributor.authorChlup, Zdeněkcs
dc.contributor.authorJaroš, Josefcs
dc.contributor.authorČástková, Kláracs
dc.contributor.authorDrdlík, Danielcs
dc.contributor.authorPospíšil, Jakubcs
dc.contributor.authorHampl, Alešcs
dc.contributor.authorKoutná, Irenacs
dc.contributor.authorCihlář, Jaroslavcs
dc.coverage.issue2cs
dc.coverage.volume10cs
dc.date.accessioned2022-04-28T10:52:01Z
dc.date.available2022-04-28T10:52:01Z
dc.date.issued2022-03-27cs
dc.description.abstractThe positive effect of silica on microstructural, mechanical and biological properties of calcium phosphate scaffolds was investigated in this study. Scaffolds containing 3D interconnected spherical macropores with diameters in the range of 300-770 mu m were prepared by the polymer replica technique. Reinforcement was achieved by incorporating 5 to 20 wt % of colloidal silica into the initial hydroxyapatite (HA) powder. The HA was fully decomposed into alpha and beta-tricalcium phosphate, and silica was transformed into cristobalite at 1200 degrees C. Silica reinforced scaffolds exhibited compressive strength in the range of 0.3 to 30 MPa at the total porosity of 98-40%. At a nominal porosity of 75%, the compressive strength was doubled compared to scaffolds without silica. When immersed into a cultivation medium, the formation of an apatite layer on the surfaces of scaffolds indicated their bioactivity. The supportive effect of the silicon enriched scaffolds was examined using three different types of cells (human adipose-derived stromal cells, L929, and ARPE-19 cells). The cells firmly adhered to the surfaces of composite scaffolds with no sign of induced cell death. Scaffolds were non-cytotoxic and had good biocompatibility in vitro. They are promising candidates for therapeutic applications in regenerative medicine.en
dc.formattextcs
dc.format.extent356-369cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJournal of Asian Ceramic Societies. 2022, vol. 10, issue 2, p. 356-369.en
dc.identifier.doi10.1080/21870764.2022.2053278cs
dc.identifier.issn2187-0764cs
dc.identifier.other177591cs
dc.identifier.urihttp://hdl.handle.net/11012/204117
dc.language.isoencs
dc.publisherInformacs
dc.relation.ispartofJournal of Asian Ceramic Societiescs
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2187-0764/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBioceramicsen
dc.subjectscaffolden
dc.subjectcalcium phosphateen
dc.subjectsilicaen
dc.subjectcompressive strengthen
dc.titleMacroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-177591en
sync.item.dbtypeVAVen
sync.item.insts2022.08.01 12:52:32en
sync.item.modts2022.08.01 12:14:14en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé keramické materiálycs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Inovační technologie v keramicecs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. ÚMVI-odbor keramiky a polymerůcs
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Pokročilé keramické materiály
Inovační technologie v keramice
ÚMVI-odbor keramiky a polymerů