Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

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dc.contributor.authorŠtěpánková, Hanacs
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorŠplíchal, Zbyněkcs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorŠvec, Pavelcs
dc.contributor.authorVaculovič, Tomášcs
dc.contributor.authorPřibyl, Jancs
dc.contributor.authorKormunda, Martincs
dc.contributor.authorRex, Simonacs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.coverage.issue1cs
dc.coverage.volume20cs
dc.date.accessioned2023-03-27T14:54:48Z
dc.date.available2023-03-27T14:54:48Z
dc.date.issued2023-02-01cs
dc.description.abstractAlthough the general concept of nanotechnology relies on exploitation of size-dependent properties of nano -scaled materials, the relation between the size/morphology of nanoparticles with their biological activity re-mains not well understood. Therefore, we aimed at investigating the biological activity of Se nanoparticles, one of the most promising candidates of nanomaterials for biomedicine, possessing the same crystal structure, but differing in morphology (nanorods vs. spherical particles) and aspect ratios (AR, 11.5 vs. 22.3 vs. 1.0) in human cells and BALB/c mice. Herein, we report that in case of nanorod-shaped Se nanomaterials, AR is a critical factor describing their cytotoxicity and biocompatibility. However, spherical nanoparticles (AR 1.0) do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se nanorods. Beside of cytotoxicity, we also show that morphology and size substantially affect the uptake and intracellular fate of Se nanomaterials. In line with in vitro data, in vivo i.v. administration of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR nanorods. Moreover, we revealed that Se nano -materials are able to alter intracellular redox homeostasis, and affect the acidic intracellular vesicles and cyto-skeletal architecture in a size-and morphology-dependent manner. Although the tested nanoparticles were produced from the similar sources, their behavior differs markedly, since each type is promising for several various application scenarios, and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.en
dc.formattextcs
dc.format.extent489-500cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBioactive Materials. 2023, vol. 20, issue 1, p. 489-500.en
dc.identifier.doi10.1016/j.bioactmat.2022.06.014cs
dc.identifier.issn2452-199Xcs
dc.identifier.other183017cs
dc.identifier.urihttp://hdl.handle.net/11012/209249
dc.language.isoencs
dc.relation.ispartofBioactive Materialscs
dc.relation.urihttps://doi.org/10.1016/j.bioactmat.2022.06.014cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2452-199X/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectAspect ratioen
dc.subjectBiocompatibilityen
dc.subjectNanotoxicologyen
dc.subjectNanorodsen
dc.titleUnveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphologyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183017en
sync.item.dbtypeVAVen
sync.item.insts2023.03.27 16:54:48en
sync.item.modts2023.03.27 16:16:33en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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