Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings
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Date
2019-01-02
Authors
Škubalová, Zuzana
Michálková, Hana
Strmiska, Vladislav
Dostálová, Simona
Michálek, Petr
Křížková, Soňa
Adam, Vojtěch
Heger, Zbyněk
0000-0002-7036-1640Advisor
Referee
Mark
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Mendel University in Brno
Abstract
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are used in topical dermatologic preparation and also as white pigment. Due to these properties their use in human life is more and more frequent. Despite the fact that nano dimension brings various beneficial properties, it could bring also bad features. Therefore, in this study, we evaluated a cytotoxicity of two types of biphasic TiO2 NPs using distinct cells of epithelial origin. We found that TiO2 NPs can induce cytotoxic stress resulting in fragmentation of DNA.
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Peer-reviewed
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Published version
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en
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(C) Mendel University in Brno