Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

Simple item page
dc.contributor.authorPekařík, Vladimírcs
dc.contributor.authorPešková, Mariecs
dc.contributor.authorDuben, Jakubcs
dc.contributor.authorRemeš, Marekcs
dc.contributor.authorHeger, Zbyněkcs
dc.coverage.issue1cs
dc.coverage.volume10cs
dc.date.issued2020-07-23cs
dc.description.abstractAllyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific Reports. 2020, vol. 10, issue 1, p. 1-10.en
dc.identifier.doi10.1038/s41598-020-69336-wcs
dc.identifier.issn2045-2322cs
dc.identifier.orcid0000-0003-3462-7517cs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.other164788cs
dc.identifier.researcheridU-4722-2017cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.urihttp://hdl.handle.net/11012/194807
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofScientific Reportscs
dc.relation.urihttps://www.nature.com/articles/s41598-020-69336-wcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2045-2322/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectfluorogenic detectionen
dc.subjectpalladiumen
dc.subjectplatinumen
dc.subjectorganometallic compoundsen
dc.subjectpolyacrylamide gelsen
dc.titleDirect fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gelsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164788en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:49:59en
sync.item.modts2025.01.17 15:19:33en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids.pdf
Size:
1.77 MB
Format:
Adobe Portable Document Format
Description:
Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids.pdf
Download
Collections
Chytré nanonástroje