Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects

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dc.contributor.authorHaddad, Yazan Abdulmajeed Eyadhcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.coverage.issue130cs
dc.coverage.volume10cs
dc.date.issued2017-05-03cs
dc.description.abstractSome therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling. The wide range of cross-interactions between Trk receptors and neurotrophins vary in selectivity, affinity and function. In this study, we discuss new perspectives to the manipulation of side-effects via a better understanding of the cross-interactions at the molecular level, derived by computational methods. Available crystal structures of Trk receptors and neurotrophins are a valuable resource for exploitation via molecular mechanics (MM) and dynamics (MD). The study of the energetics and dynamics of neurotrophins or neurotrophic peptides interacting with Trk receptors will provide insight to structural regions that may be candidates for drug targeting and signaling pathway selection.en
dc.formattextcs
dc.format.extent1-7cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationFrontiers in Molecular Neuroscience. 2017, vol. 10, issue 130, p. 1-7.en
dc.identifier.doi10.3389/fnmol.2017.00130cs
dc.identifier.issn1662-5099cs
dc.identifier.orcid0000-0002-7844-4336cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.other137551cs
dc.identifier.researcheridJ-2985-2015cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.scopus36070488100cs
dc.identifier.urihttp://hdl.handle.net/11012/69383
dc.language.isoencs
dc.publisherFrontierscs
dc.relation.ispartofFrontiers in Molecular Neurosciencecs
dc.relation.urihttp://journal.frontiersin.org/article/10.3389/fnmol.2017.00130/fullcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1662-5099/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectdrug side-effecten
dc.subjectmolecular dynamicsen
dc.subjectmolecular mechanicsen
dc.subjectneurotrophic tyrosine kinase receptoren
dc.subjectneurotrophinen
dc.subjecttropomyosin receptor kinaseen
dc.titleTrk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effectsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-137551en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:23en
sync.item.modts2025.01.17 16:44:38en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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