Heart rate and age modulate retinal pulsatile patterns

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dc.contributor.authorLabounková, Ivanacs
dc.contributor.authorLabounek, Renécs
dc.contributor.authorKolář, Radimcs
dc.contributor.authorTornow, Ralf-Petercs
dc.contributor.authorBabbs, Charles F.cs
dc.contributor.authorMcClelland, Collincs
dc.contributor.authorMiller, Benjamin R.cs
dc.contributor.authorNestrašil, Igorcs
dc.coverage.issue1cs
dc.coverage.volume5cs
dc.date.issued2022-06-14cs
dc.description.abstractVideo-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationCommunications Biology. 2022, vol. 5, issue 1, p. 1-10.en
dc.identifier.doi10.1038/s42003-022-03441-6cs
dc.identifier.issn2399-3642cs
dc.identifier.orcid0000-0002-0469-6397cs
dc.identifier.other178352cs
dc.identifier.researcheridC-8547-2014cs
dc.identifier.urihttp://hdl.handle.net/11012/208117
dc.language.isoencs
dc.publisherNATURE PORTFOLIOcs
dc.relation.ispartofCommunications Biologycs
dc.relation.urihttps://www.nature.com/articles/s42003-022-03441-6cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2399-3642/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectblood flowen
dc.subjectimage processingen
dc.subjectocular hypertensionen
dc.subjectoptical imagingen
dc.subjecttranslational researchen
dc.titleHeart rate and age modulate retinal pulsatile patternsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-178352en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:54en
sync.item.modts2025.01.17 15:19:18en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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