Heart rate and age modulate retinal pulsatile patterns
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Date
2022-06-14
Authors
Labounková, Ivana
Labounek, René
Kolář, Radim
Tornow, Ralf-Peter
Babbs, Charles F.
McClelland, Collin
Miller, Benjamin R.
Nestrašil, Igor
ORCID
0000-0002-0469-6397Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
NATURE PORTFOLIO
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Abstract
Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.
Description
Citation
Communications Biology. 2022, vol. 5, issue 1, p. 1-10.
https://www.nature.com/articles/s42003-022-03441-6
https://www.nature.com/articles/s42003-022-03441-6
Document type
Peer-reviewed
Document version
Published version
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Language of document
en