Corticosteroid Treatment Prediction using Chest X-ray and Clinical Data

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dc.contributor.authorMezina, Anzhelikacs
dc.contributor.authorGenzor, Samuelcs
dc.contributor.authorBurget, Radimcs
dc.contributor.authorMyška, Vojtěchcs
dc.contributor.authorMizera, Jancs
dc.contributor.authorOmetov, Aleksandrcs
dc.coverage.issueDecember 24cs
dc.coverage.volume24cs
dc.date.issued2024-12-02cs
dc.description.abstractBackground and Objective: Severe courses of COVID-19 disease can lead to long-term complications. The post-acute phase of COVID-19 refers to the persistent or new symptoms. This problem is becoming more relevant with the increasing number of patients who have contracted COVID-19 and the emergence of new virus variants. In this case, preventive treatment with corticosteroids can be applied. However, not everyone benefits from the treatment, moreover, it can have severe side effects. Currently, no study would analyze who benefits from the treatment. Methods: This work introduces a novel approach to the recommendation of Corticosteroid (CS) treatment for patients in the post-acute phase. We have used a novel combination of clinical data, including blood tests, spirometry, and X-ray images from 273 patients. These are very challenging to collect, especially from patients in the post-acute phase of COVID-19. To our knowledge, no similar dataset exists in the literature. Moreover, we have proposed a unique methodology that combines machine learning and deep learning models based on Vision Transformer (ViT) and InceptionNet, preprocessing techniques, and pretraining strategies to deal with the specific characteristics of our data. Results: The experiments have proved that combining clinical data with CXR images achieves 8% higher accuracy than independent analysis of CXR images. The proposed method reached 80.0% accuracy (78.7% balanced accuracy) and a ROC-AUC of 0.89. Conclusions: The introduced system for CS treatment prediction using our neural network and learning algorithm is unique in this field of research. Here, we have shown the efficiency of using mixed data and proved it on real-world data. The paper also introduces the factors that could be used to predict long-term complications. Additionally, this system was deployed to the hospital environment as a recommendation tool, which admits the clinical application of the proposed methodology.en
dc.formattextcs
dc.format.extent53-65cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationComputational and Structural Biotechnology Journal. 2024, vol. 24, issue December 24, p. 53-65.en
dc.identifier.doi10.1016/j.csbj.2023.11.057cs
dc.identifier.issn2001-0370cs
dc.identifier.orcid0000-0003-1849-5390cs
dc.identifier.orcid0000-0002-9364-2330cs
dc.identifier.other185577cs
dc.identifier.researcheridX-5469-2018cs
dc.identifier.scopus23011250200cs
dc.identifier.urihttp://hdl.handle.net/11012/245188
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofComputational and Structural Biotechnology Journalcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2001037023004713cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2001-0370/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectImage classificationen
dc.subjectChest X-ray imagesen
dc.subjectVision transformeren
dc.subjectTreatment predictionen
dc.subjectClinical dataen
dc.subjectPost-acute COVID-19en
dc.titleCorticosteroid Treatment Prediction using Chest X-ray and Clinical Dataen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-185577en
sync.item.dbtypeVAVen
sync.item.insts2025.02.10 16:19:40en
sync.item.modts2025.02.10 13:32:08en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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