Porcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosa

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dc.contributor.authorLipový, Břetislavcs
dc.contributor.authorVacek, Lukášcs
dc.contributor.authorPolaštík Kleknerová, Dominikacs
dc.contributor.authorJeklová, Editacs
dc.contributor.authorLišková, Lenkacs
dc.contributor.authorHoloubek, Jakubcs
dc.contributor.authorMatýsková, Dominikacs
dc.contributor.authorRůžička, Filipcs
dc.coverage.issue6cs
dc.coverage.volume69cs
dc.date.accessioned2025-03-28T16:15:52Z
dc.date.available2025-03-28T16:15:52Z
dc.date.issued2024-09-10cs
dc.description.abstractPseudomonas aeruginosa poses a significant threat to both immunocompetent and immunocompromised individuals, often resulting in life -threatening infections. With increasing antimicrobial resistance, novel therapeutic strategies are urgently needed. Although animal models are crucial for preclinical studies, limited data are available for porcine models, more specifically for P. aeruginosa complicated skin and soft tissue infections (cSSTIs). This study presents a novel porcine model inducing and sustaining cSSTI for 14 days. Six pigs (120 wounds) were used for the development of infections, and within this group, two pigs (40 wounds) were used to evaluate the progression of the cSSTI infection. The model demonstrated bacterial loads of more than 10 7 CFU/ gram of tissue or higher. The cSSTI fully developed within three days and remained well above these levels until day 14 post -infection. Due to the immunocompetence of this model, all the immunological processes associated with the response to the presence of infection and the wound healing process are preserved.en
dc.formattextcs
dc.format.extent191-197cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationVETERINARNI MEDICINA. 2024, vol. 69, issue 6, p. 191-197.en
dc.identifier.doi10.17221/25/2024-VETMEDcs
dc.identifier.issn1805-9392cs
dc.identifier.other189940cs
dc.identifier.urihttps://hdl.handle.net/11012/250699
dc.language.isoencs
dc.publisherCZECH ACADEMY AGRICULTURAL SCIENCEScs
dc.relation.ispartofVETERINARNI MEDICINAcs
dc.relation.urihttps://vetmed.agriculturejournals.cz/artkey/vet-202406-0004_porcine-model-of-a-complicated-skin-and-soft-tissue-infection-caused-by-pseudomonas-aeruginosa.phpcs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1805-9392/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectESKAPE pathogenen
dc.subjectmodel developmenten
dc.subjectpigen
dc.subjectwounden
dc.titlePorcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189940en
sync.item.dbtypeVAVen
sync.item.insts2025.03.28 17:15:52en
sync.item.modts2025.03.28 14:32:04en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé biomateriálycs
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