Assessing Laryngeal Neuromotor Activity from Phonation

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dc.contributor.authorGomez-Vilda, Pedrocs
dc.contributor.authorGómez-Rodellar, Andréscs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorÁlvarez-Marquina, Agustíncs
dc.contributor.authorPalacios-Alonso, Danielcs
dc.contributor.authorRektorová, Irenacs
dc.coverage.issue6cs
dc.coverage.volume35cs
dc.date.accessioned2025-06-09T10:57:26Z
dc.date.available2025-06-09T10:57:26Z
dc.date.issued2025-06-01cs
dc.description.abstractNeurodegenerative motor disorders affect the neuromuscular system challenging daily life and normal activity. Parkinson's Disease (PD) is among the most prevalent ones, with a large impact and rising prevalence rates. Speech is most affected by PD as far as phonatory and articulatory performance is concerned. Neuromotor activity (NMA) alterations have an impact on larynx muscles responsible for vocal fold adduction and abduction, hampering phonation stability and regularity. The main muscular articulators involved in phonation control are the cricothyroid (tensor) and thyroarytenoid (relaxer) systems, regulated by two distinct direct neuromotor pathways, activated by the precentral gyrus laryngeal control areas. These articulations control the musculus vocalis, directly responsible for regular vocal fold vibration. An indirect estimation of the muscular tension produced by inverse filtering may split into two independent channels, assumed to be the tensor and relaxer neuromotor pathways such as the differential neuromotor activity (DNMA). The amplitude distributions of both DNMA channels allow comparing phonations from PD-affected persons (PDPs) and age-matched healthy control participants (HCPs) with respect to a set of reference mid-age normative participants (RSPs). The comparisons are carried out by Jensen-Shannon distributions of PDP and HCP phonations with respect to those of RSPs. A dataset of 96 phonation samples from participants balanced by gender is used to train a set of decision tree classifiers (DTCs) to distinguish PDP from HCP phonation. The best results from 10-fold cross-validation offered accumulated mismatches of 0.09 and 0.1292 for male and female subsets. The sensitivity, specificity, and accuracy of the classification results when separating PDP from HCP phonatios were 93.33%, 88.23%, and 90.63% (male PDP versus HCP) and 92.86%, 83.33%, and 87.50% (female PDP versus HCP), providing a stratification of PDPs and HCPs by objective disease grading from explainable AI (XAI) methods.en
dc.formattextcs
dc.format.extent1-19cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationINTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2025, vol. 35, issue 6, p. 1-19.en
dc.identifier.doi10.1142/S0129065725500297cs
dc.identifier.issn0129-0657cs
dc.identifier.orcid0000-0002-6195-193Xcs
dc.identifier.other198056cs
dc.identifier.researcheridK-4001-2015cs
dc.identifier.scopus35746344400cs
dc.identifier.urihttps://hdl.handle.net/11012/251328
dc.language.isoencs
dc.publisherWorld Scientificcs
dc.relation.ispartofINTERNATIONAL JOURNAL OF NEURAL SYSTEMScs
dc.relation.urihttps://www.worldscientific.com/doi/10.1142/S0129065725500297cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0129-0657/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectNeuromotor diseasesen
dc.subjectphonation function assessmenten
dc.subjectlaryngeal neuromotor activity monitoringen
dc.titleAssessing Laryngeal Neuromotor Activity from Phonationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-198056en
sync.item.dbtypeVAVen
sync.item.insts2025.06.09 12:57:26en
sync.item.modts2025.06.09 12:33:31en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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