A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

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dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorCernei, Natalia Vladimirovnacs
dc.contributor.authorKudr, Jiřícs
dc.contributor.authorGumulec, Jaromírcs
dc.contributor.authorBlažková, Ivacs
dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorEckschlager, Tomášcs
dc.contributor.authorStiborová, Mariecs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorKizek, Renécs
dc.coverage.issue11cs
dc.coverage.volume14cs
dc.date.issued2013-11-01cs
dc.description.abstractDoxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, -alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.en
dc.formattextcs
dc.format.extent21629-21646cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Molecular Sciences. 2013, vol. 14, issue 11, p. 21629-21646.en
dc.identifier.doi10.3390/ijms141121629cs
dc.identifier.issn1422-0067cs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.orcid0000-0002-8259-1566cs
dc.identifier.orcid0000-0002-9658-3444cs
dc.identifier.orcid0000-0001-7607-5058cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.other145130cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.researcheridK-2578-2016cs
dc.identifier.researcheridD-7638-2012cs
dc.identifier.researcheridE11072012cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.scopus37080103000cs
dc.identifier.scopus55769747816cs
dc.identifier.scopus14012648400cs
dc.identifier.urihttp://hdl.handle.net/11012/137222
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofInternational Journal of Molecular Sciencescs
dc.relation.urihttps://www.mdpi.com/1422-0067/14/11/21629cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1422-0067/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmyocardiumen
dc.subjectcardiomyopathyen
dc.subjectinteractionen
dc.subjectamide bonden
dc.subjectspectrophotometryen
dc.subjection-exchange liquid chromatographyen
dc.titleA Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicinen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-145130en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:49:46en
sync.item.modts2025.01.17 18:49:20en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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