Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration

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dc.contributor.authorHashemi, Amircs
dc.contributor.authorEzati, Masoumehcs
dc.contributor.authorPartovi Nasr, Minoocs
dc.contributor.authorZumberg, Innacs
dc.contributor.authorProvazník, Valentinecs
dc.coverage.issue6cs
dc.coverage.volume9cs
dc.date.accessioned2024-05-13T08:45:51Z
dc.date.available2024-05-13T08:45:51Z
dc.date.issued2024-01-31cs
dc.description.abstractExtracellular vesicles have emerged as promising tools in regenerative medicine due to their inherent ability to facilitate intercellular communication and modulate cellular functions. These nanosized vesicles transport bioactive molecules, such as proteins, lipids, and nucleic acids, which can affect the behavior of recipient cells and promote tissue regeneration. However, the therapeutic application of these vesicles is frequently constrained by their rapid clearance from the body and inability to maintain a sustained presence at the injury site. In order to overcome these obstacles, hydrogels have been used as extracellular vesicle delivery vehicles, providing a localized and controlled release system that improves their therapeutic efficacy. This Review will examine the role of extracellular vesicle-loaded hydrogels in tissue regeneration, discussing potential applications, current challenges, and future directions. We will investigate the origins, composition, and characterization techniques of extracellular vesicles, focusing on recent advances in exosome profiling and the role of machine learning in this field. In addition, we will investigate the properties of hydrogels that make them ideal extracellular vesicle carriers. Recent studies utilizing this combination for tissue regeneration will be highlighted, providing a comprehensive overview of the current research landscape and potential future directions.en
dc.formattextcs
dc.format.extent6184-6218cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS OMEGA. 2024, vol. 9, issue 6, p. 6184-6218.en
dc.identifier.doi10.1021/acsomega.3c08280cs
dc.identifier.issn2470-1343cs
dc.identifier.orcid0000-0002-9919-3812cs
dc.identifier.orcid0000-0001-7250-1945cs
dc.identifier.orcid0000-0002-3422-7938cs
dc.identifier.other188186cs
dc.identifier.researcheridAAQ-4108-2021cs
dc.identifier.researcheridF-4121-2012cs
dc.identifier.scopus57209822630cs
dc.identifier.scopus6701729526cs
dc.identifier.urihttps://hdl.handle.net/11012/245489
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS OMEGAcs
dc.relation.urihttps://pubs.acs.org/doi/full/10.1021/acsomega.3c08280cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2470-1343/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectExtracellular vesiclesen
dc.subjecthydrogelsen
dc.subjectcontrolled releaseen
dc.subjecttissue regenerationen
dc.subjectmachine learningen
dc.subjectbiofabricationen
dc.subjectbiocompatibilityen
dc.subjectand regenerative medicine.en
dc.titleExtracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regenerationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188186en
sync.item.dbtypeVAVen
sync.item.insts2024.05.13 10:45:51en
sync.item.modts2024.05.13 10:14:07en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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