Characterization of multi-walled carbon nanotubes double-functionalization with cytostatic drug etoposide and phosphorothioate oligodeoxynucleotides

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dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorMoulick, Amitavacs
dc.contributor.authorNguyen, Hoai Vietcs
dc.contributor.authorKremplová, Monikacs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorHynek, Davidcs
dc.contributor.authorEckschlager, Tomášcs
dc.contributor.authorStiborová, Mariecs
dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorKízek, Renécs
dc.coverage.issue9cs
dc.coverage.volume10cs
dc.date.issued2015-09-01cs
dc.description.abstractCarbon nanomaterials possess unique structural and physicochemical properties, and thus they are broadly utilized as carriers for a variety of therapeutic agents in nanomedicinal applications. Herein we present an electrochemical characterization of binding capability of acidic oxidized multi-walled carbon nanotubes (oMWCNTs) modified with poly(ethylene glycol) towards common cytostatic drug etoposide (or VP-16). The comparison of willingness of oMWCNTs and MWCNTs-PEG to form complexes with etoposide revealed significantly higher capacity in PEGylated variant of carbon nanotubes (the 15 mM etoposide loading capacity was approximately 46.4% in 2 mg of MWCNT-PEG or 28.1% in equal amount of oMWCNT). To obtain a multifunctional nanotransporter we employed the phosphorothioate oligodeoxynucleotide (PODN), which could further extend the possible biological effects of MWCNT-PEG-Etoposide complex. By using square wave voltammetry, the binding capacity of 2 mg of MWCNT-PEG-Etoposide (15 mM) towards PODNs was determined to be 4.5 mu M. Such characterized multifunctional complex can be further employed for biological testing on chemoresistant tumors, such as non-small-cell lung cancer, to enhance the treatment efficiency.en
dc.formattextcs
dc.format.extent7707-7719cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationINTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE. 2015, vol. 10, issue 9, p. 7707-7719.en
dc.identifier.issn1452-3981cs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.orcid0000-0001-5769-6748cs
dc.identifier.orcid0000-0003-4216-9544cs
dc.identifier.orcid0000-0002-7318-6470cs
dc.identifier.orcid0000-0001-7607-5058cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.other123363cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.researcheridI-9677-2016cs
dc.identifier.researcheridE-5711-2012cs
dc.identifier.researcheridE-5702-2012cs
dc.identifier.researcheridE11072012cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.scopus55783172600cs
dc.identifier.scopus6603604023cs
dc.identifier.scopus14012648400cs
dc.identifier.urihttp://hdl.handle.net/11012/201457
dc.language.isoencs
dc.publisherESGcs
dc.relation.ispartofINTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCEcs
dc.relation.urihttp://www.electrochemsci.org/papers/vol10/100907707.pdfcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1452-3981/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectAntisense oligodeoxynucleotidesen
dc.subjectCarbon nanomaterialsen
dc.subjectElectrochemistryen
dc.subjectNanotechnologyen
dc.subjectPoly(ethylene) glycolen
dc.titleCharacterization of multi-walled carbon nanotubes double-functionalization with cytostatic drug etoposide and phosphorothioate oligodeoxynucleotidesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-123363en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:08en
sync.item.modts2025.01.17 16:38:41en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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