Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A-protein aggregation

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dc.contributor.authorGomez Perez, Inmaculada Jennifercs
dc.contributor.authorKřížková, Petracs
dc.contributor.authorDolečková, Annacs
dc.contributor.authorCardo, Luciacs
dc.contributor.authorWetzl, Cecíliacs
dc.contributor.authorPizúrová, Naděždacs
dc.contributor.authorPrato, Mauriziocs
dc.contributor.authorMedalová, Jiřinacs
dc.contributor.authorZajíčková, Lenkacs
dc.coverage.issue2cs
dc.coverage.volume36cs
dc.date.accessioned2025-02-03T14:50:57Z
dc.date.available2025-02-03T14:50:57Z
dc.date.issued2024-02-01cs
dc.description.abstractMultifunctional nanoparticles could be the hallmark for the treatment of neurodegenerative diseases. Dissociation of protein aggregates causing neuronal damage and transfer of specific drugs which can downregulate neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-D-Aspartate-receptors (NMDA) and then reducing calcium influx are among the main factors to consider for proper therapy. Here, we present a multiplatform based on nitrogen-doped graphene quantum dots (NGQDs) with such functionalities. The NGQDs were functionalized with Memantine, the clinically used drug, via covalent and non-covalent coupling, and we confirmed that the pharmaceutical activity was not altered. Apart from that, using xCELLigence technology and flow cytometric analysis of ABC transporter function, we uncovered that the ABC transporters of the blood-brain barrier (BBB) do not affect the ability of NGQD to cross BBB. Surprisingly, this study found that NGQDs have an inhibitory effect on NMDA receptors, thus supporting the action of Memantine. Moreover, NGQDs and their derivatives demonstrated the potential to dissociate beta-amyloid aggregates while possessing features suitable for bioimaging in various cell lines.en
dc.formattextcs
dc.format.extent1-9cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationApplied Materials Today. 2024, vol. 36, issue 2, p. 1-9.en
dc.identifier.doi10.1016/j.apmt.2024.102072cs
dc.identifier.issn2352-9407cs
dc.identifier.orcid0000-0002-6906-8906cs
dc.identifier.other188954cs
dc.identifier.researcheridE-3010-2012cs
dc.identifier.urihttps://hdl.handle.net/11012/249999
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofApplied Materials Todaycs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2352940724000180?via%3Dihubcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2352-9407/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectCarbon dotsen
dc.subjectMemantineen
dc.subjectProtein aggregationen
dc.subjectBlood-brain barrieren
dc.subjectBioimagingen
dc.titleMultifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A-protein aggregationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188954en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:57en
sync.item.modts2025.01.17 15:28:48en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Plazmové technologie pro materiálycs
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