Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

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dc.contributor.authorPacík, Daliborcs
dc.contributor.authorPlevová, Marianacs
dc.contributor.authorUrbanová, Luciecs
dc.contributor.authorLacková, Zuzanacs
dc.contributor.authorStrmiska, Vladislavcs
dc.contributor.authorNečas, Aloiscs
dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorAdam, Vojtěchcs
dc.coverage.issue4958cs
dc.coverage.volume8cs
dc.date.issued2018-12-01cs
dc.description.abstractThe hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.en
dc.formattextcs
dc.format.extent1-5cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific Reports. 2018, vol. 8, issue 4958, p. 1-5.en
dc.identifier.doi10.1038/s41598-018-23072-4cs
dc.identifier.issn2045-2322cs
dc.identifier.orcid0000-0003-4254-5992cs
dc.identifier.orcid0000-0002-7036-1640cs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.other147109cs
dc.identifier.researcheridH-2870-2018cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.urihttp://hdl.handle.net/11012/72395
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofScientific Reportscs
dc.relation.urihttp://link.springer.com/article/10.1038/s41598-018-23072-4cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2045-2322/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectprostate cancer (PCa)en
dc.subjectsarcosineen
dc.subjectsniffer dogen
dc.titleIdentification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinomaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-147109en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:25en
sync.item.modts2025.01.17 18:45:29en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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