Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment

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dc.contributor.authorTesařová, Barboracs
dc.contributor.authorDostálová, Simonacs
dc.contributor.authorHynek, Davidcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.date.accessioned2018-08-23T10:52:54Z
dc.date.available2018-08-23T10:52:54Z
dc.date.issued2017-12-31cs
dc.description.abstractMany researchers are developing nanocarriers in order to minimalize side effects of cytotoxic drugs during cancer treatment via chemotherapy. Nanocarriers can serve as a suitable platform for targeted drug delivery. To overcome their failure in in vivo use, the effects of surface modifications (PEGylation and PASylation) of natural nanocarriers based on apoferritin were tested in this work. Various properties of these modified apoferitin nanoparticles were studied, such as their size or degree of hemolysis. TEM characterization was also performed. The formation of hard coronas on these particles in plasma environment was evaluated using SDS-PAGE electrophoresis. The best biocompatibility results were obtained using apoferritin nanoparticles with PEG surface modification.en
dc.formattextcs
dc.format.extent937-942cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMendelNet 2017. 2017, p. 937-942.en
dc.identifier.isbn978-80-7509-529-9cs
dc.identifier.other148770cs
dc.identifier.urihttp://hdl.handle.net/11012/84183
dc.language.isoencs
dc.publisherMendel University in Brnocs
dc.relation.ispartofMendelNet 2017cs
dc.relation.urihttps://mendelnet.cz/artkey/mnt-201701-0110_Surface-PEGylation-and-PASylation-to-regulate-nanoparticle-interactions-with-biological-environment.php?back=/magno/mnt/2017/mn1.php?secid=4cs
dc.rights(C) Mendel University in Brnocs
dc.rights.accessopenAccesscs
dc.subjectApoferritinen
dc.subjectnanomedicineen
dc.subjectprotein coronasen
dc.subjectsurface modificationsen
dc.titleSurface PEGylation and PASylation to regulate nanoparticle interactions with biological environmenten
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-148770en
sync.item.dbtypeVAVen
sync.item.insts2020.03.30 16:58:35en
sync.item.modts2020.03.30 15:52:17en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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