Magneto-Fluorescent Microrobots with Selective Detection Intelligence for High-Energy Explosives and Antibiotics in Aqueous Environments

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dc.contributor.authorNatarajan, Senthil Nathancs
dc.contributor.authorOral, Çaatay Mertcs
dc.contributor.authorPumera, Martincs
dc.coverage.issue14cs
dc.coverage.volume17cs
dc.date.accessioned2025-05-30T08:56:52Z
dc.date.available2025-05-30T08:56:52Z
dc.date.issued2025-03-27cs
dc.description.abstractFluorescence-based sensing is a straightforward and powerful technique with high sensitivity for the detection of a wide range of chemical and biological analytes. Integrating the high sensing capabilities of fluorescent probes with wireless navigation systems can enable the extension of their operational range, even in challenging scenarios with limited accessibility or involving hazardous substances. This study presents the development of molecularly engineered magneto-fluorescent microrobots based on the push-pull quinonoids by incorporating magnetic nanoparticles using a reprecipitation approach with the aim of detecting high-energy explosives and antibiotics in aqueous environments. The magnetic components in the microrobots offer remotely controlled navigability toward the intended target areas under the guidance of external magnetic fields. Upon interactions with either explosives (picric acid) or antibiotics (tetracycline), the microrobots' intrinsic fluorescence switches to a "fluorescence off" state, enabling material-based intelligence for sensing applications. The molecular-level interactions that underlie "on-off" fluorescence state switching upon engagement with target molecules are elucidated through extensive spectroscopy, microscopy, and X-ray diffraction analyses. The microrobots' selectivity toward target molecules is achieved by designing microrobots with amine functionalities capable of intermolecular hydrogen bonding with the acidic hydroxyl group of picric acid, leading to the formation of water-soluble charge transfer picrate complexes through proton transfer. Similarly, proton transfer interactions play a key role in tetracycline detection. The selective fluorescence switching performance of microrobots in fluidic channel experiments illustrates their selective sensing intelligence for target molecules in an externally controlled manner, highlighting their promising characteristics for sensing applications in real-world scenarios.en
dc.formattextcs
dc.format.extent21691-21704cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS applied materials & interfaces. 2025, vol. 17, issue 14, p. 21691-21704.en
dc.identifier.doi10.1021/acsami.5c02259cs
dc.identifier.issn1944-8252cs
dc.identifier.orcid0000-0001-5220-2104cs
dc.identifier.orcid0000-0001-5846-2951cs
dc.identifier.other197901cs
dc.identifier.researcheridF-2724-2010cs
dc.identifier.scopus57203728973cs
dc.identifier.urihttps://hdl.handle.net/11012/251187
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS applied materials & interfacescs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsami.5c02259cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1944-8252/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmagnetic microrobotsen
dc.subjectorganic pollutantsen
dc.subjectenvironmentalmonitoringen
dc.subjectcharge transfer complexesen
dc.subjectfluorescencesensingen
dc.titleMagneto-Fluorescent Microrobots with Selective Detection Intelligence for High-Energy Explosives and Antibiotics in Aqueous Environmentsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-197901en
sync.item.dbtypeVAVen
sync.item.insts2025.05.30 10:56:52en
sync.item.modts2025.05.30 10:33:36en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
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