Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients

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dc.contributor.authorBrabenec, Lubošcs
dc.contributor.authorKlobušiaková, Patríciacs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorRektorová, Irenacs
dc.coverage.issue1cs
dc.coverage.volume94cs
dc.date.issued2022-01-01cs
dc.description.abstractIntroduction Impaired copy of intersecting pentagons from the Mini-Mental State Examination (MMSE), has been used to assess dementia in Parkinson's disease (PD). We used a digitizing tablet during the pentagon copying test (PCT) as a potential tool for evaluating early cognitive deficits in PD without major cognitive impairment. We also aimed to uncover the neural correlates of the identified parameters using whole-brain magnetic resonance imaging (MRI). Methods We enrolled 27 patients with PD without major cognitive impairment and 25 age-matched healthy controls (HC). We focused on drawing parameters using a digitizing tablet. Parameters with between-group differences were correlated with cognitive outcomes and were used as covariates in the whole-brain voxel-wise analysis using voxel-based morphometry; familywise error (FWE) threshold p < 0.001. Results PD patients differed from HC in attention domain z-scores (p < 0.0001). In terms of tablet parameters, the groups differed in Shannon entropy (horizontal in-air, p = 0.003), which quantifies the movements between two strokes. In PD, a correlation was found between the median of Shannon entropy (horizontal in-air) and attention z-scores (R = 0.55, p = 0.006). The VBM revealed an association between our drawing parameter of interest and gray matter (GM) volume variability in the right superior parietal lobe (SPL). Conclusion Using a digitizing tablet during the PCT, we identified a novel entropy-based parameter that differed between the nondemented PD and HC groups. This in-air parameter correlated with the level of attention and was linked to GM volume variability of the region engaged in spatial attention.en
dc.formattextcs
dc.format.extent45-48cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPARKINSONISM & RELATED DISORDERS. 2022, vol. 94, issue 1, p. 45-48.en
dc.identifier.doi10.1016/j.parkreldis.2021.11.037cs
dc.identifier.issn1353-8020cs
dc.identifier.orcid0000-0002-6195-193Xcs
dc.identifier.other175128cs
dc.identifier.researcheridK-4001-2015cs
dc.identifier.scopus35746344400cs
dc.identifier.urihttp://hdl.handle.net/11012/203237
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofPARKINSONISM & RELATED DISORDERScs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1353802021004442cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1353-8020/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectParkinson's diseaseen
dc.subjectkinematic analysisen
dc.subjectpentagon copying testen
dc.subjectin-air movementen
dc.subjectShannon entropyen
dc.titleShannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patientsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-175128en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:42:20en
sync.item.modts2025.01.17 16:50:48en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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