Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients

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dc.contributor.authorBrabenec, Lubošcs
dc.contributor.authorKlobušiaková, Patríciacs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorRektorová, Irenacs
dc.coverage.issue1cs
dc.coverage.volume94cs
dc.date.issued2022-01-01cs
dc.description.abstractIntroduction Impaired copy of intersecting pentagons from the Mini-Mental State Examination (MMSE), has been used to assess dementia in Parkinson's disease (PD). We used a digitizing tablet during the pentagon copying test (PCT) as a potential tool for evaluating early cognitive deficits in PD without major cognitive impairment. We also aimed to uncover the neural correlates of the identified parameters using whole-brain magnetic resonance imaging (MRI). Methods We enrolled 27 patients with PD without major cognitive impairment and 25 age-matched healthy controls (HC). We focused on drawing parameters using a digitizing tablet. Parameters with between-group differences were correlated with cognitive outcomes and were used as covariates in the whole-brain voxel-wise analysis using voxel-based morphometry; familywise error (FWE) threshold p < 0.001. Results PD patients differed from HC in attention domain z-scores (p < 0.0001). In terms of tablet parameters, the groups differed in Shannon entropy (horizontal in-air, p = 0.003), which quantifies the movements between two strokes. In PD, a correlation was found between the median of Shannon entropy (horizontal in-air) and attention z-scores (R = 0.55, p = 0.006). The VBM revealed an association between our drawing parameter of interest and gray matter (GM) volume variability in the right superior parietal lobe (SPL). Conclusion Using a digitizing tablet during the PCT, we identified a novel entropy-based parameter that differed between the nondemented PD and HC groups. This in-air parameter correlated with the level of attention and was linked to GM volume variability of the region engaged in spatial attention.en
dc.description.abstractIntroduction Impaired copy of intersecting pentagons from the Mini-Mental State Examination (MMSE), has been used to assess dementia in Parkinson's disease (PD). We used a digitizing tablet during the pentagon copying test (PCT) as a potential tool for evaluating early cognitive deficits in PD without major cognitive impairment. We also aimed to uncover the neural correlates of the identified parameters using whole-brain magnetic resonance imaging (MRI). Methods We enrolled 27 patients with PD without major cognitive impairment and 25 age-matched healthy controls (HC). We focused on drawing parameters using a digitizing tablet. Parameters with between-group differences were correlated with cognitive outcomes and were used as covariates in the whole-brain voxel-wise analysis using voxel-based morphometry; familywise error (FWE) threshold p < 0.001. Results PD patients differed from HC in attention domain z-scores (p < 0.0001). In terms of tablet parameters, the groups differed in Shannon entropy (horizontal in-air, p = 0.003), which quantifies the movements between two strokes. In PD, a correlation was found between the median of Shannon entropy (horizontal in-air) and attention z-scores (R = 0.55, p = 0.006). The VBM revealed an association between our drawing parameter of interest and gray matter (GM) volume variability in the right superior parietal lobe (SPL). Conclusion Using a digitizing tablet during the PCT, we identified a novel entropy-based parameter that differed between the nondemented PD and HC groups. This in-air parameter correlated with the level of attention and was linked to GM volume variability of the region engaged in spatial attention.en
dc.formattextcs
dc.format.extent45-48cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPARKINSONISM & RELATED DISORDERS. 2022, vol. 94, issue 1, p. 45-48.en
dc.identifier.doi10.1016/j.parkreldis.2021.11.037cs
dc.identifier.issn1353-8020cs
dc.identifier.orcid0000-0002-6195-193Xcs
dc.identifier.other175128cs
dc.identifier.researcheridK-4001-2015cs
dc.identifier.scopus35746344400cs
dc.identifier.urihttp://hdl.handle.net/11012/203237
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofPARKINSONISM & RELATED DISORDERScs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1353802021004442cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1353-8020/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectParkinson's diseaseen
dc.subjectkinematic analysisen
dc.subjectpentagon copying testen
dc.subjectin-air movementen
dc.subjectShannon entropyen
dc.subjectParkinson's disease
dc.subjectkinematic analysis
dc.subjectpentagon copying test
dc.subjectin-air movement
dc.subjectShannon entropy
dc.titleShannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patientsen
dc.title.alternativeShannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patientsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-175128en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 14:12:22en
sync.item.modts2025.10.14 09:57:47en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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