Intelligent Magnetic Microrobots with Fluorescent Internal Memory for Monitoring Intragastric Acidity

Simple item page
dc.contributor.authorNatarajan, Senthil Nathancs
dc.contributor.authorOral, Çaatay Mertcs
dc.contributor.authorNovobilský, Adamcs
dc.contributor.authorPumera, Martincs
dc.coverage.issue29cs
dc.coverage.volume34cs
dc.date.accessioned2025-02-03T14:50:37Z
dc.date.available2025-02-03T14:50:37Z
dc.date.issued2024-07-01cs
dc.description.abstractThis study investigates the dynamic fluctuations of pH caused by gastric acid secretion, a process of both biological and clinical significance, with microrobots. Abnormal patterns of acidity often indicate gastrointestinal diseases, underlying the importance of precise intragastric pH monitoring. Traditional methods using fluorescent probes face challenges due to their faint solid-state fluorescence, limited target specificity, and accuracy. To overcome these obstacles, pH-responsive fluorescent organic microparticles decorated with magnetite (Fe3O4) nanoparticles are engineered. These microrobots exhibit a unique fluorescence switching capability at a critical pH, enabling the monitoring of gastric acidity. The magnetic part of these microrobots ensures magnetic maneuverability to enable targeted navigation. The microrobots' fluorescence switching mechanism is elucidated through comprehensive spectroscopy, microscopy, and X-ray diffraction analyses, revealing molecular-level structural transformations upon interaction with gastric acid and antacids. These transformations, specifically protonation and deprotonation of the microrobots' fluorescent components, prompt a distinct fluorescence response correlating with pH shifts. In vitro and ex vivo experiments, simulating stomach conditions, confirm the microrobots' efficacy in pH-responsive imaging. The results showcase the promising diagnostic potential of microrobots for gastrointestinal tract diseases, marking a significant advancement in imaging-based medical diagnostics at targeted locations. Multi-fluorescent pH-sensitive molecular material-based magnetic microrobots are developed to monitor pH variations in the stomach. Magnetically-induced motion, collection, and navigation of the microrobots facilitate access to gastric fluid and enable pH monitoring at target locations. Additionally, fluorescence switching of the microrobots at different gastric fluid acidity enables real-time monitoring of pH changes. imageen
dc.formattextcs
dc.format.extent1-12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationAdvanced functional materials. 2024, vol. 34, issue 29, p. 1-12.en
dc.identifier.doi10.1002/adfm.202401463cs
dc.identifier.issn1616-3028cs
dc.identifier.orcid0000-0001-5220-2104cs
dc.identifier.orcid0000-0001-5846-2951cs
dc.identifier.other188812cs
dc.identifier.researcheridF-2724-2010cs
dc.identifier.scopus57203728973cs
dc.identifier.urihttps://hdl.handle.net/11012/249989
dc.language.isoencs
dc.publisherWILEY-V C H VERLAG GMBHcs
dc.relation.ispartofAdvanced functional materialscs
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/adfm.202401463cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1616-3028/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectfluorescence sensingen
dc.subjectgastric pH monitoringen
dc.subjectmagnetic microrobotsen
dc.subjectpH responseen
dc.titleIntelligent Magnetic Microrobots with Fluorescent Internal Memory for Monitoring Intragastric Acidityen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188812en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:37en
sync.item.modts2025.01.31 13:32:13en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024Senthilnathan.pdf
Size:
5.71 MB
Format:
Adobe Portable Document Format
Description:
file 2024Senthilnathan.pdf
Download
Collections
Energie budoucnosti a inovace