Interaction of platinum-based cytostatics and platinum nanoparticles with metallothionein - potencial source of the antitumor drug resistence

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dc.contributor.authorZelníčková, Jaroslavacs
dc.contributor.authorNejdl, Lukášcs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorAdam, Vojtěchcs
dc.date.issued2018-03-31cs
dc.description.abstractPlatinum-based cytostatic represent a unique class of DNA-damaging antitumor agents and they are one the most frequently used drugs in oncology. Problem is that some kind of cancer is resistant against this type of cytostatics. This resistance can be potentially caused by metalloproteins such as metallothioneins. MTs belong to the group of intracellular cystine-rich, metal-binding proteins and hold a number of functions in body. One of them is detoxification of heavy metals. This ability of MTs can cause a decreased therapeutic effect of platinum-based cytostatics. In this work, the interaction between two isoforms of MTs (MT3 and MT2a) and several types of platinum cytostatics (oxaliplatin, carboplatin and cisplatin) as well as platinum nanoparticles (size of 10 and 40 nm) was examined by fluorimetric analysis using a fluorescence zinc indicator (Fluozin-3). Both, stationary fluorescence spectrometry and capillary electrophoresis with laser-induced fluorescence detection (ex - 488 nm, em - 530 nm) was used in the study.en
dc.formattextcs
dc.format.extent505-510cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNANOCON 2017. 2018, p. 505-510.en
dc.identifier.isbn978-80-87294-81-9cs
dc.identifier.orcid0000-0001-6332-8917cs
dc.identifier.orcid0000-0002-8288-3999cs
dc.identifier.orcid0000-0003-4216-9544cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.other148682cs
dc.identifier.researcheridN-9991-2014cs
dc.identifier.researcheridE-5711-2012cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.scopus12040049600cs
dc.identifier.scopus6603604023cs
dc.identifier.urihttp://hdl.handle.net/11012/178374
dc.language.isoencs
dc.publisherTANGERcs
dc.relation.ispartofNANOCON 2017cs
dc.relation.urihttps://nanocon2017.tanger.cz/cz/cs
dc.rights(C) TANGERcs
dc.rights.accessopenAccesscs
dc.subjectPlatinumen
dc.subjectnanoparticleen
dc.subjectcytostaticsen
dc.subjectfluorescenceen
dc.subjectmetalloproteinen
dc.titleInteraction of platinum-based cytostatics and platinum nanoparticles with metallothionein - potencial source of the antitumor drug resistenceen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-148682en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:13en
sync.item.modts2025.01.17 15:26:03en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. oddělení-MEL-SIXcs
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