Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay

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dc.contributor.authorGarehbaghi, Sanamcs
dc.contributor.authorAshrafi, Amirmansoorcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorRichtera, Lukášcs
dc.coverage.issue1cs
dc.coverage.volume20cs
dc.date.accessioned2023-08-30T10:53:30Z
dc.date.available2023-08-30T10:53:30Z
dc.date.issued2023-06-01cs
dc.description.abstractGold nanozymes (GNZs) have been widely used in biosensing and bioassay due to their interesting catalytic activities that enable the substitution of natural enzyme. This review explains different catalytic activities of GNZs that can be achieved by applying different modifications to their surface. The role of Gold nanoparticles (GNPs) in mimicking oxidoreductase, helicase, phosphatase were introduced. Moreover, the effect of surface properties and modifications on each catalytic activity was thoroughly discussed. The application of GNZs in biosensing and bioassay was classified in five categories based on the combination of the enzyme like activities and enhancing/ inhibition of the catalytic activities in presence of the target analyte/s that is realized by proper surface modification engineering. These categories include catalytic activity enhancer, reversible catalytic activity inhibitor, binding selectivity enhancer, agglomeration base, and multienzyme like activity, which are explained and exemplified in this review. It also gives examples of those modifications that enable the application of GNZs for in vivo biosensing and bioassays.en
dc.formattextcs
dc.format.extent16cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMaterials Today Bio. 2023, vol. 20, issue 1, 16 p.en
dc.identifier.doi10.1016/j.mtbio.2023.100656cs
dc.identifier.issn2590-0064cs
dc.identifier.orcid0000-0002-4843-8664cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.orcid0000-0002-8288-3999cs
dc.identifier.other183975cs
dc.identifier.researcheridAAG-8096-2020cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.researcheridN-9991-2014cs
dc.identifier.scopus57205660261cs
dc.identifier.scopus12040049600cs
dc.identifier.urihttp://hdl.handle.net/11012/213828
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofMaterials Today Biocs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2590006423001163cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2590-0064/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectGold nanozymeen
dc.subjectCatalytic activityen
dc.subjectSurface modificationen
dc.subjectBiosensing and bioassayen
dc.titleSurface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassayen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183975en
sync.item.dbtypeVAVen
sync.item.insts2023.08.30 12:53:30en
sync.item.modts2023.08.30 12:14:39en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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