Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona

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dc.contributor.authorTesařová, Barboracs
dc.contributor.authorDostálová, Simonacs
dc.contributor.authorCharousová, Markétacs
dc.contributor.authorŠkubalová, Zuzanacs
dc.contributor.authorGuráň, Romancs
dc.contributor.authorDo, Tomášcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.date.issued2019-01-02cs
dc.description.abstractThe effects of surface modifications (PEGylation and PASylation) of natural nanocarriers based on apoferritin (FRT) were tested in this work. The main goals of performed PEGylation/PASylation were decreased protein corona formation leading to better internalization of drugs into diseased cells and therefore higher efficiency of treatment. The influence of created protein coronas on the amount of internalized experimental drug ellipticine (Elli) was evaluated via fluorescence microscopy. Various properties of these modified nanoparticles were studied, such as their cytotoxicity or release kinetics of Elli. According to performed experiments, PAS-10 modification appeared as the most appropriate surface modification.en
dc.formattextcs
dc.format.extent542-547cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMendelNet 2018. 2019, p. 542-547.en
dc.identifier.isbn978-80-7509-597-8cs
dc.identifier.orcid0000-0001-9027-4002cs
dc.identifier.orcid0000-0002-2912-714Xcs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.other156247cs
dc.identifier.researcheridC-2610-2016cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.urihttp://hdl.handle.net/11012/178389
dc.language.isoencs
dc.publisherMendel University in Brnocs
dc.relation.ispartofMendelNet 2018cs
dc.relation.urihttps://mendelnet.cz/artkey/mnt-201801-0115_Effect-of-apoferritin-surface-biomacromolecular-modification-on-cellular-uptake-and-inhibition-of-protein-coron.php?back=/magno/mnt/2018/mn1.php?secid=4cs
dc.rights(C) Mendel University in Brnocs
dc.rights.accessopenAccesscs
dc.subjectapoferritinen
dc.subjectnanomedicineen
dc.subjectPASylationen
dc.subjectPEGylationen
dc.subjectprotein coronasen
dc.titleEffect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein coronaen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-156247en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:49:49en
sync.item.modts2025.01.17 16:48:11en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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