Different concepts for creating antibacterial yet biocompatible surfaces: Adding bactericidal element, grafting therapeutic agent through COOH plasma polymer and their combination

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dc.contributor.authorPermyakova, Elizavetacs
dc.contributor.authorManakhov, Antoncs
dc.contributor.authorKiryukhantsev-Korneev, Philipcs
dc.contributor.authorSheveyko, A.N.cs
dc.contributor.authorGudz, Kristina Yu.cs
dc.contributor.authorKovalskii, Andreycs
dc.contributor.authorPolčák, Josefcs
dc.contributor.authorZhitnyak, I.Y.cs
dc.contributor.authorGloushankova, Natalia A.cs
dc.contributor.authorDyatlov, Ivan A.cs
dc.contributor.authorIgnatov, Sergei G.cs
dc.contributor.authorErshov, Sergeycs
dc.contributor.authorShtansky, Dmitry V.cs
dc.coverage.issue1cs
dc.coverage.volume556cs
dc.date.accessioned2021-10-05T10:53:53Z
dc.date.available2021-10-05T10:53:53Z
dc.date.issued2021-08-01cs
dc.description.abstractAntibacterial coatings have become a rapidly developing field of research, strongly stimulated by the increasing urgency of identifying alternatives to the traditional administration of antibiotics. Such coatings can be deposited onto implants and other medical devices and prevent the inflammations caused by hospital-acquired infections. Nevertheless, the design of antibacterial yet biocompatible and bioactive surfaces is a challenge that biological community has faced for many years but the "materials of dream" have not yet been developed. In this work, the biocompatible yet antibacterial multi-layered films were prepared by a combination of magnetron sputtering (TiCaPCON film), ion implantation (Ag-doped TiCaPCON film), plasma polymerization (COOH layer), and the final immobilization of gentamicin (GM) and heparin (Hepa) molecules. The layer chemistry was thoroughly investigated by means of FTIR and X-ray photoelectron spectroscopies. It was found that the immobilization of therapeutic components occurs throughout the entire thickness of the plasma-deposited COOH layer. The influence of each type of bactericide (Ag+ ions, GM, and Hepa) on antibacterial activity and cell proliferation was analyzed. Our films were cytocompatible and demonstrated superior bactericidal efficiency toward antibioticresistant bacterial E. coli K261 strain. Increased toxicity while using the combination of Ag nanoparticles and COOH plasma polymer is discussed.en
dc.formattextcs
dc.format.extent149751-1-149751-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationApplied Surface Science. 2021, vol. 556, issue 1, p. 149751-1-149751-11.en
dc.identifier.doi10.1016/j.apsusc.2021.149751cs
dc.identifier.issn0169-4332cs
dc.identifier.other172148cs
dc.identifier.urihttp://hdl.handle.net/11012/201752
dc.language.isoencs
dc.publisherELSEVIERcs
dc.relation.ispartofApplied Surface Sciencecs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0169433221008278?via%3Dihubcs
dc.rights(C) ELSEVIERcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0169-4332/cs
dc.subjectAntibacterial surfacesen
dc.subjectPlasmaen
dc.subjectGentamicinen
dc.subjectSilveren
dc.subjectHeparinen
dc.subjectXPSen
dc.titleDifferent concepts for creating antibacterial yet biocompatible surfaces: Adding bactericidal element, grafting therapeutic agent through COOH plasma polymer and their combinationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-172148en
sync.item.dbtypeVAVen
sync.item.insts2021.10.05 12:53:53en
sync.item.modts2021.10.05 12:14:34en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Sdílená laboratoř RP1cs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav fyzikálního inženýrstvícs
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