Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy

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dc.contributor.authorKopřivová, Hanacs
dc.contributor.authorKiss, Kateřinacs
dc.contributor.authorKrbal, Lukášcs
dc.contributor.authorStejskal, Václavcs
dc.contributor.authorBuday, Jakubcs
dc.contributor.authorPořízka, Pavelcs
dc.contributor.authorKaška, Milancs
dc.contributor.authorRyška, Alešcs
dc.contributor.authorKaiser, Jozefcs
dc.coverage.issue6cs
dc.coverage.volume1310cs
dc.date.accessioned2024-08-22T08:02:38Z
dc.date.available2024-08-22T08:02:38Z
dc.date.issued2024-06-29cs
dc.description.abstractThe diagnosis of malignant melanoma, often an inconspicuous but highly aggressive tumor, is most commonly done by histological examination, while additional diagnostic methods on the level of elements and molecules are constantly being developed. Several studies confirmed differences in the chemical composition of healthy and tumor tissue. Our study presents the potential of the LIBS (Laser -Induced -Breakdown Spectroscopy) technique as a diagnostic tool in malignant melanoma (MM) based on the quantitative changes in elemental composition in cancerous tissue. Our patient group included 17 samples of various types of malignant melanoma and one sample of healthy skin tissue as a control. To achieve a clear perception of results, we have selected two biogenic elements (calcium and magnesium), which showed a dissimilar distribution in cancerous tissue from its healthy surroundings. Moreover, we observed indications of different concentrations of these elements in different subtypes of malignant melanoma, a hypothesis that requires confirmation in a more extensive sample set. The information provided by the LIBS Imaging method could potentially be helpful not only in the diagnostics of tumor tissue but also be beneficial in broadening the knowledge about the tumor itself.en
dc.formattextcs
dc.format.extent1-8cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationAnalytica Chimica Acta. 2024, vol. 1310, issue 6, p. 1-8.en
dc.identifier.doi10.1016/j.aca.2024.342663cs
dc.identifier.issn1873-4324cs
dc.identifier.orcid0009-0006-9030-0681cs
dc.identifier.orcid0000-0003-1453-5068cs
dc.identifier.orcid0000-0002-8604-7365cs
dc.identifier.orcid0000-0002-7397-125Xcs
dc.identifier.other189156cs
dc.identifier.researcheridG-9463-2014cs
dc.identifier.researcheridD-6800-2012cs
dc.identifier.scopus55312098800cs
dc.identifier.scopus7402184758cs
dc.identifier.urihttps://hdl.handle.net/11012/249393
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofAnalytica Chimica Actacs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0003267024004641cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1873-4324/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectCutaneous canceren
dc.subjectSkin tumoren
dc.subjectDiagnosticsen
dc.subjectDigital histopathologyen
dc.subjectChemical analysisen
dc.subjectOptical emission spectroscopyen
dc.titleImaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189156en
sync.item.dbtypeVAVen
sync.item.insts2024.08.22 10:02:38en
sync.item.modts2024.08.20 14:33:26en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav fyzikálního inženýrstvícs
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Pokročilé instrumentace a metody pro charakterizace materiálů