Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings

Abstract

Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are used in topical dermatologic preparation and also as white pigment. Due to these properties their use in human life is more and more frequent. Despite the fact that nano dimension brings various beneficial properties, it could bring also bad features. Therefore, in this study, we evaluated a cytotoxicity of two types of biphasic TiO2 NPs using distinct cells of epithelial origin. We found that TiO2 NPs can induce cytotoxic stress resulting in fragmentation of DNA.Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are used in topical dermatologic preparation and also as white pigment. Due to these properties their use in human life is more and more frequent. Despite the fact that nano dimension brings various beneficial properties, it could bring also bad features. Therefore, in this study, we evaluated a cytotoxicity of two types of biphasic TiO2 NPs using distinct cells of epithelial origin. We found that TiO2 NPs can induce cytotoxic stress resulting in fragmentation of DNA.