Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

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dc.contributor.authorVojníková, Michaelacs
dc.contributor.authorSúkupová, Martinacs
dc.contributor.authorŠtefánik, Michalcs
dc.contributor.authorStraková, Petracs
dc.contributor.authorHaviernik, Jancs
dc.contributor.authorKapolková, Kateřinacs
dc.contributor.authorGruberová, Eliškacs
dc.contributor.authorRašková, Kláracs
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorŠvec, Pavelcs
dc.contributor.authorPešková, Mariecs
dc.contributor.authorHuvarová, Ivanacs
dc.contributor.authorRůžek, Danielcs
dc.contributor.authorSalát, Jiřícs
dc.contributor.authorPekařík, Vladimírcs
dc.contributor.authorEyer, Luděkcs
dc.contributor.authorHeger, Zbyněkcs
dc.coverage.issue4cs
dc.coverage.volume19cs
dc.date.accessioned2025-02-03T14:50:47Z
dc.date.available2025-02-03T14:50:47Z
dc.date.issued2024-04-30cs
dc.description.abstractAs highlighted by recent pandemic outbreaks, antiviral drugs are crucial resources in the global battle against viral diseases. Unfortunately, most antiviral drugs are characterized by a plethora of side effects and low efficiency/poor bioavailability owing to their insolubility. This also applies to the arylnaphthalide lignin family member, diphyllin (Diph). Diph acts as a vacuolar ATPase inhibitor and has been previously identified as a promising candidate with broad-spectrum antiviral activity. However, its physicochemical properties preclude its efficient administration in vivo, complicating preclinical testing.en
dc.formattextcs
dc.format.extent3907-3917cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Nanomedicine. 2024, vol. 19, issue 4, p. 3907-3917.en
dc.identifier.doi10.2147/IJN.S452119cs
dc.identifier.issn1178-2013cs
dc.identifier.orcid0000-0002-3131-3064cs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.other188515cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.urihttps://hdl.handle.net/11012/249995
dc.language.isoencs
dc.publisherDove Presscs
dc.relation.ispartofInternational Journal of Nanomedicinecs
dc.relation.urihttps://www.dovepress.com/nanoformulation-of-the-broad-spectrum-hydrophobic-antiviral-vacuolar-a-peer-reviewed-fulltext-article-IJNcs
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1178-2013/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/cs
dc.subjectdrug deliveryen
dc.subjectSARS-CoV-2en
dc.subjectTBEVen
dc.subjectWNVen
dc.subjectZika virusen
dc.titleNanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritinen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188515en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:47en
sync.item.modts2025.01.17 16:43:53en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Laserová spektroskopiecs
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