Micro-CT, Mechanical, and Histological Examination of the Effect of Local Adjuvants on Porcine Cortical Bone Following Intralesional Curettage of Bone Tumors

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dc.contributor.authorApostolopoulos, Vasileioscs
dc.contributor.authorBoháč, Petrcs
dc.contributor.authorMarcián, Petrcs
dc.contributor.authorStaniczková Zambo, Ivacs
dc.contributor.authorPazourek, Lukášcs
dc.contributor.authorMahdal, Michalcs
dc.contributor.authorNeradil, Jakubcs
dc.contributor.authorNávrat, Tomášcs
dc.contributor.authorTomáš, Tomášcs
dc.coverage.issue2024cs
dc.coverage.volume31cs
dc.date.issued2024-05-14cs
dc.description.abstractBackground and Objectives Curettage is the removal of a tumor from the bone while preserving the surrounding healthy cortical bone, and is associated with higher rates of local recurrence. To lower these rates, curettage should be combined with local adjuvants, although their use is associated with damage to nearby healthy bone. Objective The purpose of this analysis is to determine the effect of local adjuvants on cortical porcine bone by using micro-computed tomography (micro-CT) along with histological and mechanical examination. Methods Local adjuvants were applied to porcine specimens under defined conditions. To assess changes in bone mineral density (BMD), a micro-CT scan was used. The pixel gray values of the volume of interest (VOI) were evaluated per specimen and converted to BMD values. The Vickers hardness test was employed to assess bone hardness (HV). The depth of necrosis was measured histologically using hematoxylin and eosin-stained tissue sections. Results A noticeable change in BMD was observed on the argon beam coagulation (ABC) sample. Comparable hardness values were measured on samples following electrocautery and ABC, and lowering of bone hardness was obtained in the case of liquid nitrogen. Extensive induced depth of necrosis was registered in the specimen treated with liquid nitrogen. Conclusion This study determined the effect of local adjuvants on cortical bone by using micro-CT along with histological and mechanical examination. Phenolization and liquid nitrogen application caused a decrease in bone hardness. The bone density was affected in the range of single-digit percentage values. Liquid nitrogen induced extensive depth of necrosis with a wide variance of values.en
dc.formattextcs
dc.format.extent6282-6290cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationANNALS OF SURGICAL ONCOLOGY. 2024, vol. 31, issue 2024, p. 6282-6290.en
dc.identifier.doi10.1245/s10434-024-15397-4cs
dc.identifier.issn1068-9265cs
dc.identifier.orcid0009-0006-8718-101Xcs
dc.identifier.orcid0000-0002-9458-9690cs
dc.identifier.orcid0000-0003-2772-3551cs
dc.identifier.other188592cs
dc.identifier.researcheridE-7359-2017cs
dc.identifier.researcheridQ-4147-2017cs
dc.identifier.scopus55156647700cs
dc.identifier.scopus15042816200cs
dc.identifier.urihttp://hdl.handle.net/11012/245529
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relationOperační program Jan Amos Komenskýcs
dc.relation.ispartofANNALS OF SURGICAL ONCOLOGYcs
dc.relation.projectIdCZ.02.01.01/00/22_008/0004634
dc.relation.urihttps://link.springer.com/article/10.1245/s10434-024-15397-4cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1068-9265/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectLocal adjuvantsen
dc.subjectGiant cell tumor of boneen
dc.subjectmicro-CTen
dc.subjectBone hardnessen
dc.subjectBone necrosisen
dc.titleMicro-CT, Mechanical, and Histological Examination of the Effect of Local Adjuvants on Porcine Cortical Bone Following Intralesional Curettage of Bone Tumorsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
project.funder.nameMŠMT
sync.item.dbidVAV-188592en
sync.item.dbtypeVAVen
sync.item.insts2024.10.14 11:03:53en
sync.item.modts2024.08.28 10:32:04en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. ÚMTMB-odbor biomechanikycs
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