G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes

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dc.contributor.authorBrázda, Václavcs
dc.contributor.authorŠislerová, Luciecs
dc.contributor.authorCucchiarini, Annecs
dc.contributor.authorMergny, Jean-Louiscs
dc.coverage.issue2cs
dc.coverage.volume6cs
dc.date.accessioned2025-02-03T14:38:46Z
dc.date.available2025-02-03T14:38:46Z
dc.date.issued2024-05-30cs
dc.description.abstractCurrent methods of processing archaeological samples combined with advances in sequencing methods lead to disclosure of a large part of H. neanderthalensis and Denisovans genetic information. It is hardly surprising that the genome variability between modern humans, Denisovans and H. neanderthalensis is relatively limited. Genomic studies may provide insight on the metabolism of extinct human species or lineages. Detailed analysis of G-quadruplex sequences in H. neanderthalensis and Denisovans mitochondrial DNA showed us interesting features. Relatively similar patterns in mitochondrial DNA are found compared to modern humans, with one notable exception for H. neanderthalensis. An interesting difference between H. neanderthalensis and H. sapiens corresponds to a motif found in the D-loop region of mtDNA, which is responsible for mitochondrial DNA replication. This area is directly responsible for the number of mitochondria and consequently for the efficient energy metabolism of cell. H. neanderthalensis harbor a long uninterrupted run of guanines in this region, which may cause problems for replication, in contrast with H. sapiens, for which this run is generally shorter and interrupted. One may propose that the predominant H. sapiens motif provided a selective advantage for modern humans regarding mtDNA replication and function.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNAR Genomics and Bioinformatics. 2024, vol. 6, issue 2, p. 1-10.en
dc.identifier.doi10.1093/nargab/lqae060cs
dc.identifier.issn2631-9268cs
dc.identifier.orcid0000-0003-2837-4226cs
dc.identifier.other189109cs
dc.identifier.researcheridF-9582-2011cs
dc.identifier.urihttps://hdl.handle.net/11012/249900
dc.language.isoencs
dc.publisherOxford University Presscs
dc.relation.ispartofNAR Genomics and Bioinformaticscs
dc.relation.urihttps://academic.oup.com/nargab/article/6/2/lqae060/7685155cs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2631-9268/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectmitochondriaen
dc.subjectgenome evolutionen
dc.subjectG-quadruplexen
dc.subjectreplicationen
dc.subjectpaleogenomicsen
dc.titleG-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189109en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:46en
sync.item.modts2025.01.28 12:32:09en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
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