Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges

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dc.contributor.authorKastelik-Hryniewiecka, Annacs
dc.contributor.authorJewula, Pawelcs
dc.contributor.authorBakalorz, Karolinacs
dc.contributor.authorKramer-Marek, Gabrielacs
dc.contributor.authorKuźnik, Nikodemcs
dc.coverage.issue1cs
dc.coverage.volume16cs
dc.date.accessioned2022-02-15T15:54:27Z
dc.date.available2022-02-15T15:54:27Z
dc.date.issued2022-01-14cs
dc.description.abstractRecently, the demand for hybrid PET/MRI imaging techniques has increased significantly, which has sparked the investigation into new ways to simultaneously track multiple molecular targets and improve the localization and expression of biochemical markers. Multimodal imaging probes have recently emerged as powerful tools for improving the detection sensitivity and accuracy-both important factors in disease diagnosis and treatment; however, only a limited number of bimodal probes have been investigated in preclinical models. Herein, we briefly describe the strengths and limitations of PET and MRI modalities and highlight the need for the development of multimodal molecularly-targeted agents. We have tried to thoroughly summarize data on bimodal probes available on PubMed. Emphasis was placed on their design, safety profiles, pharmacokinetics, and clearance properties. The challenges in PET/MR probe development using a number of illustrative examples are also discussed, along with future research directions for these novel conjugates.en
dc.formattextcs
dc.format.extent8465-8493cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Nanomedicine. 2022, vol. 16, issue 1, p. 8465-8493.en
dc.identifier.doi10.2147/IJN.S336299cs
dc.identifier.issn1178-2013cs
dc.identifier.other175939cs
dc.identifier.urihttp://hdl.handle.net/11012/203917
dc.language.isoencs
dc.publisherDove Medical Presscs
dc.relation.ispartofInternational Journal of Nanomedicinecs
dc.relation.urihttps://www.dovepress.com/targeted-petmri-imaging-super-probes-a-critical-review-of-opportunitie-peer-reviewed-fulltext-article-IJNcs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1178-2013/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectmedical imagingen
dc.subjectbioresponsive probesen
dc.subjecttargetingen
dc.subjectcontrast agentsen
dc.subjectrelaxivityen
dc.subjectclearanceen
dc.titleTargeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challengesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-175939en
sync.item.dbtypeVAVen
sync.item.insts2022.02.22 12:54:06en
sync.item.modts2022.02.22 12:15:08en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Magneto-Optická a THz Spektroskopiecs
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