Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head

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dc.contributor.authorTornow, Ralf-Petercs
dc.contributor.authorKolář, Radimcs
dc.contributor.authorOdstrčilík, Jancs
dc.contributor.authorLabounková, Ivanacs
dc.contributor.authorHorn, Folkertcs
dc.coverage.issue1cs
dc.date.issued2020-09-23cs
dc.description.abstractPurpose To measure parameters of the cardiac cycle-induced pulsatile light absorption signal (plethysmography signal) of the optic nerve head (ONH) and to compare parameters between normal subjects and patients with different stages of glaucoma. Patients and methods A recently developed video ophthalmoscope was used to acquire short video sequences (10 s) of the ONH. After image registration and trend correction, the pulsatile changing light absorption at the ONH tissue (excluding large vessels) was calculated. The changing light absorption depends on the pulsatile changing blood volume. Various parameters, including peak amplitude, steepness, time-to-peak, full width at half maximum (FWHM), and pulse duration, were calculated for averaged individual pulses (heartbeats) of the plethysmography signal. This method was applied to 19 healthy control subjects and 91 subjects with ocular hypertension, as well as different stages of primary open-angle glaucoma (17 subjects with ocular hypertension, 24 with preperimetric glaucoma, and 50 with perimetric glaucoma). Results Compared to the normal subjects, significant reductions (p < 0.001) in peak amplitude and steepness were observed in the group of perimetric glaucoma patients, but no significant difference was found for time-to-peak, FWHM, and pulse duration. Peak amplitude and steepness showed high correlations with RNFL thickness (p < 0.001). Conclusions The presented low-cost video-ophthalmoscope permits measurement of the plethysmographic signal of the ONH tissue and calculation of different blood flow-related parameters. The reduced values of the amplitude and steepness parameters in perimetric glaucoma patients suggest decreased ONH perfusion and blood volume. This outcome is in agreement with results from other studies using OCT angiography and laser speckle flowgraphy, which confirm reduced capillary density in these patients.en
dc.formattextcs
dc.format.extent1-12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020, issue 1, p. 1-12.en
dc.identifier.doi10.1007/s00417-020-04934-ycs
dc.identifier.issn0721-832Xcs
dc.identifier.orcid0000-0002-0469-6397cs
dc.identifier.orcid0000-0001-7053-6183cs
dc.identifier.other165363cs
dc.identifier.researcheridC-8547-2014cs
dc.identifier.researcheridA-2237-2016cs
dc.identifier.scopus35753651000cs
dc.identifier.urihttp://hdl.handle.net/11012/195242
dc.language.isoencs
dc.publisherSpringercs
dc.relation.ispartofGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGYcs
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00417-020-04934-ycs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0721-832X/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectRetinal plethysmographyen
dc.subjectGlaucomaen
dc.subjectPerfusionen
dc.subjectBlood volumeen
dc.subjectBlood flowen
dc.titleImaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve headen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-165363en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:43en
sync.item.modts2025.01.17 16:52:03en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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