Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

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dc.contributor.authorEjneby, Malin Silvercs
dc.contributor.authorJakešová, Mariecs
dc.contributor.authorFerrero, Jose J.cs
dc.contributor.authorMigliaccio, Ludovicocs
dc.contributor.authorSahalianov, Ihorcs
dc.contributor.authorZhao, Zifangcs
dc.contributor.authorBerggren, Magnuscs
dc.contributor.authorKhodagholy, Dioncs
dc.contributor.authorDerek, Vedrancs
dc.contributor.authorGelinas, Jennifer N.cs
dc.contributor.authorGlowacki, Eric Danielcs
dc.coverage.issue1cs
dc.coverage.volume6cs
dc.date.issued2021-11-22cs
dc.description.abstractImplantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm(3) thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-mu s pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves. An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.en
dc.formattextcs
dc.format.extent741-753cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNature Biomedical Engineering. 2021, vol. 6, issue 1, p. 741-753.en
dc.identifier.doi10.1038/s41551-021-00817-7cs
dc.identifier.issn2157-846Xcs
dc.identifier.orcid0000-0002-0280-8017cs
dc.identifier.other176503cs
dc.identifier.urihttp://hdl.handle.net/11012/208151
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofNature Biomedical Engineeringcs
dc.relation.urihttps://www.nature.com/articles/s41551-021-00817-7cs
dc.rights(C) Springer Naturecs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2157-846X/cs
dc.subjectNEURAL STIMULATIONen
dc.subjectSAFETYen
dc.subjectELECTRODEen
dc.subjectEFFICACYen
dc.subjectPOWERen
dc.titleChronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitoren
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionacceptedVersionen
sync.item.dbidVAV-176503en
sync.item.dbtypeVAVen
sync.item.insts2024.10.14 11:04:04en
sync.item.modts2024.09.11 09:32:02en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Bioelektronické materiály a systémycs
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