Method Comparison for Bone Density in Multiple Myeloma Patients

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dc.contributor.authorNohel, Michalcs
dc.contributor.authorMézl, Martincs
dc.contributor.authorVálek, Vlastimilcs
dc.contributor.authorDostál, Marekcs
dc.contributor.authorChmelík, Jiřícs
dc.coverage.issue3cs
dc.coverage.volume54cs
dc.date.accessioned2025-04-04T11:56:22Z
dc.date.available2025-04-04T11:56:22Z
dc.date.issued2024-09-30cs
dc.description.abstractBone mineral density (BMD) is an important indicator of bone health, particularly in patients with conditions such as multiple myeloma. This study aims to compare three methodologies for quantifying BMD in vertebral regions affected by lytic lesions: two using data from conventional CT with different corrections for tissue composition, and one using data acquired on a dual-energy CT system. Method 1 is based on conventional CT with corrections using reference values for muscle and fat, Method 2 uses conventional CT with corrections based on the measured CT values of paraspinal muscle, and Method 3 is based on dual-energy CT. The Wilcoxon signed-rank test was used for statistical comparison, as the dataset did not follow a normal distribution. The results indicated significant differences between Methods 1 and 2 for BMD in regions of interest (ROIs) within lytic lesions, while no significant differences were found for other comparisons in this group. For vertebrae affected by multiple myeloma, significant differences were found between Methods 1 and 2, and Methods 2 and 3, but not between Methods 1 and 3. In healthy vertebrae, a significant difference was found only between Methods 2 and 3. When all ROIs were combined, significant differences were found between Methods 1 and 2, and Methods 2 and 3, with no difference between Methods 1 and 3. Future research will focus on objectively assessing the accuracy of these methods by comparing their results with a calibration phantom.en
dc.formattextcs
dc.format.extent94-100cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationLékař a technika. 2024, vol. 54, issue 3, p. 94-100.en
dc.identifier.doi10.14311/CTJ.2024.3.04cs
dc.identifier.issn0301-5491cs
dc.identifier.orcid0000-0002-2679-2160cs
dc.identifier.orcid0000-0002-4147-8727cs
dc.identifier.orcid0000-0001-9950-6279cs
dc.identifier.other190125cs
dc.identifier.researcheridGQJ-8442-2022cs
dc.identifier.researcheridA-2336-2016cs
dc.identifier.researcheridH-9359-2017cs
dc.identifier.scopus57222009745cs
dc.identifier.scopus36477866400cs
dc.identifier.scopus57188877911cs
dc.identifier.urihttps://hdl.handle.net/11012/250730
dc.language.isoencs
dc.publisherCzech Society for Biomedical Engineering and Medical Informaticscs
dc.relation.ispartofLékař a technikacs
dc.relation.urihttps://doi.org/10.14311/CTJ.2024.3.04cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0301-5491/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectSpineen
dc.subjectbone mineral densityen
dc.subjectBMDen
dc.subjectMultiple myelomaen
dc.subjectspectral CTen
dc.titleMethod Comparison for Bone Density in Multiple Myeloma Patientsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-190125en
sync.item.dbtypeVAVen
sync.item.insts2025.04.04 13:56:22en
sync.item.modts2025.04.02 11:32:06en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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