Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

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dc.contributor.authorGregg, Nicholas M.cs
dc.contributor.authorSladký, Vladimírcs
dc.contributor.authorNejedlý, Petrcs
dc.contributor.authorMívalt, Filipcs
dc.contributor.authorKim, Inyongcs
dc.contributor.authorBalzekas, Irenacs
dc.contributor.authorSturges, Beverly Kcs
dc.contributor.authorCrowe, Chelsea Mcs
dc.contributor.authorPatterson, Edward E.cs
dc.contributor.authorVan Gompel, Jamie J.cs
dc.contributor.authorLundstrom, Briancs
dc.contributor.authorLeyde, Kentcs
dc.contributor.authorDenison, Timothycs
dc.contributor.authorBrinkmann, Benjamin H.cs
dc.contributor.authorKřemen, Václavcs
dc.contributor.authorWorrell, Gregorycs
dc.coverage.issue1cs
dc.coverage.volume11cs
dc.date.accessioned2022-03-21T11:54:34Z
dc.date.available2022-03-21T11:54:34Z
dc.date.issued2021-12-20cs
dc.description.abstractChronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.en
dc.formattextcs
dc.format.extent1-12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific Reports. 2021, vol. 11, issue 1, p. 1-12.en
dc.identifier.doi10.1038/s41598-021-03555-7cs
dc.identifier.issn2045-2322cs
dc.identifier.other176543cs
dc.identifier.urihttp://hdl.handle.net/11012/203997
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofScientific Reportscs
dc.relation.urihttps://www.nature.com/articles/s41598-021-03555-7cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2045-2322/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectepilepsyen
dc.subjectDBSen
dc.subjectlong term trendsen
dc.subjectneuromodulationen
dc.titleThalamic deep brain stimulation modulates cycles of seizure risk in epilepsyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-176543en
sync.item.dbtypeVAVen
sync.item.insts2022.03.21 12:54:34en
sync.item.modts2022.03.21 12:14:58en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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