Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates)

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dc.contributor.authorKovalčík, Adriánacs
dc.contributor.authorSangroniz, Leirecs
dc.contributor.authorKalina, Michalcs
dc.contributor.authorSkopalova, Katerinacs
dc.contributor.authorHumpolíček, Petrcs
dc.contributor.authorOmastová, Máriacs
dc.contributor.authorMundigler, Norbertcs
dc.contributor.authorMüller, Alejandro J.cs
dc.coverage.issue1cs
dc.coverage.volume161cs
dc.date.issued2020-10-15cs
dc.description.abstractPoly(hydroxyalkanoates) are biodegradable and biocompatible polymers suitable for tissue engineering. Fused depositon modeling (FDM) belongs to modern rapid prototyping techniques for the fabrication of scaffolds. In this work, poly(3-hydroxybutyrate (PHB), poly(3-hydroxzbutyrate-co-3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate (PHBH) were tested for FDM. Thermal and rheological properties of industrial PHAs were compared with poly(lactic acid) (PLA), which is a biodegradable polymer commonly used for FDM. The massive decrease in viscosity and loss of molecular weight of PHB and PHBV precluded their use for FDM. On the other hand, the thermal stability of PHBH was comparable to that of PLA. PHBH scaffolds prepared by FDM exhibited excellent mechanical properties, no cytotoxicity, and large proliferation of mouse embryonic fibroblast cells within 96 h. The hydrolytic degradation of PHBH and PLA scaffolds tested in synthetic gastric juice for 52 days confirmed a faster degradation of PHBH than PLA. The decrease in molecular weight confirmed the first-order kinetics with a slightly higher (0.0169 day-1) degradation rate constant for pHBH as compared to the value (0.0107 day-1) obtainined for PLA. These results indicate that PHBH could be used to produce scaffolds by FDM with application in tissue engineering.en
dc.formattextcs
dc.format.extent364-376cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2020, vol. 161, issue 1, p. 364-376.en
dc.identifier.doi10.1016/j.ijbiomac.2020.06.022cs
dc.identifier.issn0141-8130cs
dc.identifier.orcid0000-0003-4833-7369cs
dc.identifier.orcid0000-0002-4224-0841cs
dc.identifier.other164644cs
dc.identifier.researcheridI-7386-2015cs
dc.identifier.scopus7006307069cs
dc.identifier.urihttp://hdl.handle.net/11012/195639
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULEScs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0141813020334590cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0141-8130/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectBiodegradationen
dc.subjectCytocompatibilityen
dc.subjectMechanical propertiesen
dc.subjectPoly(hydroxyalkanoates)en
dc.subjectPoly(lactic acid)en
dc.subject3D printingen
dc.titleProperties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates)en
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionacceptedVersionen
sync.item.dbidVAV-164644en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:36en
sync.item.modts2025.01.17 18:33:26en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav fyzikální a spotřební chemiecs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
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